Ke-Rong Qi, Xue Chen, Jian-Chao Si, Sheng-Chang Yang
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引用次数: 0
Abstract
Obstructive sleep apnea (OSA) affects quality of life and health in nearly 1 billion patients all over the world. With aging society, OSA increases the risk of Alzheimer's disease and leads to severe cognitive impairment. Chronic intermittent hypoxia (CIH), the core pathological mechanism of OSA, may induce synaptic plasticity damage and cognitive impairment, and decrease learning and memory and attention ability. However, the molecular mechanism underlying OSA is still not fully understood. And, there is no targeted treatment strategy for cognitive impairment in patients with OSA. Firstly, the correlation between OSA and cognitive dysfunction was summarized in this review. Secondly, the molecular mechanism of CIH-induced cognitive impairment was elucidated from the perspectives of synaptic plasticity damage, oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, mitochondrial dysfunction and autophagy. Finally, the current treatment strategy for cognitive impairment in patients with OSA was summarized.
阻塞性睡眠呼吸暂停（OSA）影响着全球近 10 亿患者的生活质量和健康。随着社会的老龄化，OSA 会增加阿尔茨海默病的风险，并导致严重的认知障碍。慢性间歇性缺氧（CIH）是OSA的核心病理机制，可诱发突触可塑性损伤和认知障碍，降低学习记忆和注意力能力。然而，OSA 的分子机制仍未完全明了。而且，目前还没有针对 OSA 患者认知障碍的靶向治疗策略。首先，本综述总结了OSA与认知功能障碍之间的相关性。其次，从突触可塑性损伤、氧化应激、炎症、内质网应激、细胞凋亡、线粒体功能障碍和自噬等角度阐明了CIH诱导认知障碍的分子机制。最后，总结了目前针对 OSA 患者认知障碍的治疗策略。
期刊介绍：
Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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