Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals.

IF 4.5 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular Pharmaceutics Pub Date : 2024-12-02 Epub Date: 2024-10-29 DOI:10.1021/acs.molpharmaceut.4c00894

B H Jaswanth Gowda, Mohammed Gulzar Ahmed, Raghu Raj Singh Thakur, Ryan F Donnelly, Lalitkumar K Vora

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Abstract

Phytochemicals, which are predominantly found in plants, hold substantial medicinal value. Despite their potential, challenges such as poor oral bioavailability and instability in the gastrointestinal tract have limited their therapeutic use. Traditional intra/transdermal drug delivery systems offer some advantages over oral administration but still suffer from issues such as limited penetration depth, slow drug release rates, and inconsistent drug absorption. In contrast, microneedles (MNs) represent a significant advancement in intra/transdermal drug delivery by providing precise control over phytochemical delivery and enhanced penetration capabilities. By circumventing skin barriers, MNs directly access dermal layers rich in blood vessels and lymphatics, thus facilitating efficient phytochemical delivery. This review extensively discusses the obstacles of traditional oral delivery and the benefits of intra/transdermal delivery routes with a particular focus on the transformative potential of MNs for phytochemical delivery. This review explores the complexities of delivering phytochemicals through intra/transdermal routes, the development and types of MNs as innovative delivery tools, and the optimal design and properties of MNs for effective phytochemical delivery. Additionally, this review examines the versatile applications of MN-mediated phytochemical delivery, including its role in administering phytophotosensitizers for photodynamic therapy, and concludes with insights into relevant patents and future perspectives.

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微针作为植物化学物质透皮给药的新兴平台。

植物化学物质主要存在于植物中，具有巨大的药用价值。尽管植物化学物质潜力巨大，但口服生物利用度低、在胃肠道中不稳定等挑战限制了其治疗用途。与口服给药相比，传统的皮内/透皮给药系统具有一些优势，但仍存在渗透深度有限、药物释放速度慢和药物吸收不稳定等问题。相比之下，微针（MNs）可精确控制植物化学物质的输送并增强渗透能力，是皮内/透皮给药领域的一大进步。通过绕过皮肤屏障，微针可直接进入富含血管和淋巴管的真皮层，从而促进植物化学物质的高效输送。本综述广泛讨论了传统口服给药的障碍和皮内/透皮给药途径的益处，尤其关注 MNs 在植物化学物质给药方面的变革潜力。本综述探讨了通过皮内/透皮途径给药植物化学物质的复杂性、作为创新给药工具的 MNs 的开发和类型，以及 MNs 在有效给药植物化学物质方面的最佳设计和特性。此外，本综述还探讨了 MN 介导的植物化学物质递送的多种应用，包括其在光动力疗法中施用植物光敏剂的作用，最后还对相关专利和未来前景进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Pharmaceutics 医学-药学

CiteScore

8.00

自引率

6.10%

发文量

391

审稿时长

2 months

期刊介绍： Molecular Pharmaceutics publishes the results of original research that contributes significantly to the molecular mechanistic understanding of drug delivery and drug delivery systems. The journal encourages contributions describing research at the interface of drug discovery and drug development. Scientific areas within the scope of the journal include physical and pharmaceutical chemistry, biochemistry and biophysics, molecular and cellular biology, and polymer and materials science as they relate to drug and drug delivery system efficacy. Mechanistic Drug Delivery and Drug Targeting research on modulating activity and efficacy of a drug or drug product is within the scope of Molecular Pharmaceutics. Theoretical and experimental peer-reviewed research articles, communications, reviews, and perspectives are welcomed.