The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Samin Abed, Amir Ebrahimi, Fatemeh Fattahi, Ghazal Kouchakali, Mahmoud Shekari-Khaniani, Sima Mansoori-Derakhshan
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引用次数: 0

Abstract

Although brain amyloid-β (Aβ) peptide buildup is the main cause of Alzheimer’s disease (AD), mitochondrial abnormalities can also contribute to the illness’s development, as either a primary or secondary factor, as programmed cell death and efficient energy generation depend on the proper operation of mitochondria. As a result, non-coding RNAs (ncRNAs) may play a crucial role in ensuring that nuclear genes related to mitochondria and mitochondrial genes function normally. Interestingly, a significant number of recent studies have focused on the impact of ncRNAs on the expression of nucleus and mitochondrial genes. Additionally, researchers have proposed some intriguing therapeutic approaches to treat and reduce the severity of AD by adjusting the levels of these ncRNAs. The goal of this work was to consolidate the existing knowledge in this field of study by systematically investigating ncRNAs, with a particular emphasis on microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs). Therefore, the impact and processes by which ncRNAs govern mitochondrial activity in the onset and progression of AD are thoroughly reviewed in this article. Collectively, the effects of ncRNAs on physiological and molecular mechanisms associated with mitochondrial abnormalities that exacerbate AD are thoroughly reviewed in the current research, while also emphasizing the relationship between disturbed mitophagy in AD and ncRNAs.

非编码 RNA 在阿尔茨海默病线粒体功能障碍中的作用
虽然脑淀粉样蛋白-β(Aβ)肽堆积是阿尔茨海默病(AD)的主要病因,但线粒体异常也可作为主要或次要因素导致该病的发生,因为细胞的程序性死亡和有效的能量生成依赖于线粒体的正常运行。因此,非编码 RNA(ncRNA)可能在确保与线粒体相关的核基因和线粒体基因正常运行方面发挥着至关重要的作用。有趣的是,近期大量研究都集中于 ncRNA 对细胞核和线粒体基因表达的影响。此外,研究人员还提出了一些耐人寻味的治疗方法,通过调整这些 ncRNAs 的水平来治疗和减轻注意力缺失症的严重程度。这项工作的目标是通过系统地研究 ncRNAs 来巩固这一研究领域的现有知识,重点是微小 RNAs(miRNAs)、长非编码 RNAs(lncRNAs)、环状 RNAs(circRNAs)和小核 RNAs(snoRNAs)。因此,本文对 ncRNA 在 AD 发病和进展过程中调控线粒体活性的影响和过程进行了深入探讨。总之,当前的研究全面综述了 ncRNA 对与线粒体异常相关的生理和分子机制的影响,这些异常会加重 AD 的病情,同时还强调了 AD 中有丝分裂紊乱与 ncRNA 之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Molecular Neuroscience
Journal of Molecular Neuroscience 医学-神经科学
CiteScore
6.60
自引率
3.20%
发文量
142
审稿时长
1 months
期刊介绍: The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.
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