Environmental Enrichment and Health Outcomes Among Low-Grade Glioma Brain Tumor Survivors.

Karl Cristie F Figuracion, Christine Mac Donald, David Hunt, Tresa McGranahan, Frances M Lewis, Jason Rockhill, Myron Goldberg, Lia M Halasz, Hilaire J Thompson
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Abstract

Abstract: BACKGROUND: Brain tumor survivors who received radiotherapy (RT) are at a disproportionately increased risk of accelerated aging and symptom burden. We aim to examine the association between environmental enrichment (EE) and health outcomes among low-grade glioma survivors who received brain RT. METHODS: The study used a cross-sectional cohort design, enrolling participants approximately 5 years from diagnosis. The construct of EE consisted of social network, physical activity, employment status, and financial stability. Berkman-Syme Social Network Index, International Physical Activity Questionnaire, Vocational Index Scale, and a Socioeconomic Questionnaire were used to measure the construct of EE. Health outcome measures included the Montreal Cognitive Assessment, Symbol Digit Modality Test, clinical brain magnetic resonance images (pre-RT, approximately 2-3 years after RT, and approximately 5 years after RT), Karnofsky Performance Status Scale, and the MD Anderson Symptom Inventory Brain Tumor Module. Ordinal logistic regression estimated the association between levels of EE and health outcomes. RESULTS: Thirty-nine participants completed the study and experienced varying levels of EE. The median age was 44 years old, ranging from 26 to 78 years old. Nineteen individuals were diagnosed with oligodendroglioma, and 18 were diagnosed with astrocytoma. Thirteen participants had low EE, 17 had moderate EE, and 9 had high EE. Although not statistically significant, we observed patterns of increasing health outcomes (Montreal Cognitive Assessment, Symbol Digit Modality Test, and Karnofsky Performance Status Scale) related to increasing levels of EE. CONCLUSION: This study is an initial exploration into the role of EE in health outcomes and survivorship programs for persons with glioma. Future research should assess EE before treatment or at the time of diagnosis and be longitudinal to accurately ascertain the association between EE and health outcomes. Comprehensive neuro-oncology survivorship programs structured to facilitate EE may reduce symptom burden, promote neuroplasticity, and improve cognitive and functional outcomes after brain radiation.

低级别胶质瘤脑肿瘤幸存者的环境富集度与健康结果。
摘要:背景:接受过放射治疗(RT)的脑肿瘤幸存者加速衰老和加重症状负担的风险不成比例地增加。我们旨在研究接受过脑部放疗的低级别胶质瘤幸存者的环境富集(EE)与健康结果之间的关联。方法:研究采用横断面队列设计,从确诊后约 5 年开始招募参与者。EE结构包括社交网络、体育活动、就业状况和经济稳定性。研究采用 Berkman-Syme 社交网络指数、国际体力活动问卷、职业指数量表和社会经济问卷来测量 EE 构建。健康结果测量包括蒙特利尔认知评估、符号数字模型测试、临床脑磁共振图像(RT前、RT后约2-3年和RT后约5年)、Karnofsky表现状态量表和MD安德森症状量表脑肿瘤模块。顺序逻辑回归估计了 EE 水平与健康结果之间的关联。结果:39 名参与者完成了研究,并经历了不同程度的 EE。年龄中位数为 44 岁,从 26 岁到 78 岁不等。19人被诊断为少突胶质细胞瘤,18人被诊断为星形细胞瘤。其中 13 人 EE 值较低,17 人 EE 值中等,9 人 EE 值较高。虽然没有统计学意义,但我们观察到健康结果(蒙特利尔认知评估、符号数字模型测试和卡诺夫斯基表现状态量表)的增加与 EE 水平的增加有关。结论:本研究初步探讨了 EE 在胶质瘤患者的健康结果和生存计划中的作用。未来的研究应在治疗前或诊断时评估 EE,并进行纵向研究,以准确确定 EE 与健康结果之间的关联。为促进EE而设计的全面神经肿瘤学幸存者计划可减轻症状负担、促进神经可塑性并改善脑放射后的认知和功能结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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