GOOD CORRELATION BETWEEN LIVER STIFFNESS MEASUREMENT AND APRI, FIB-4, PLATELET COUNT, IN PEDIATRIC AUTOIMMUNE HEPATITIS.

Q2 Medicine

Arquivos de Gastroenterologia Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI:10.1590/S0004-2803.24612024-047

Lucas Rocha Alvarenga, Natascha Silva Sandy, Gabriel Hessel, Tiago Sevá Pereira, Maria Ângela Bellomo-Brandão

{"title":"GOOD CORRELATION BETWEEN LIVER STIFFNESS MEASUREMENT AND APRI, FIB-4, PLATELET COUNT, IN PEDIATRIC AUTOIMMUNE HEPATITIS.","authors":"Lucas Rocha Alvarenga, Natascha Silva Sandy, Gabriel Hessel, Tiago Sevá Pereira, Maria Ângela Bellomo-Brandão","doi":"10.1590/S0004-2803.24612024-047","DOIUrl":null,"url":null,"abstract":"Background: There is limited evidence focusing on the use of non-invasive markers to assess liver fibrosis in pediatric chronic liver diseases.Objective: The aim of the study was to evaluate the correlation between liver stiffness measurement (LSM) using transient liver elastography (TLE) and serum non-invasive markers in pediatric autoimmune hepatitis (AIH).Methods: Cross-sectional study between May 2016 and February 2020. Twenty-eight children with AIH (age range between 3 and 20 years old) who had undergone TLE and had routine serum tests were enrolled. Patients were divided into 2 groups: (1) Liver fibrosis degree ≥F2 (TLE ≥6.45 kPa) and (2) <F2 (TLE <6.45 kPa). The groups were compared using Fisher's exact test for categorical variables and the Mann-Whitney test for quantitative variables. The correlation between TLE, APRI, FIB-4 and platelet count was assessed using the Spearman coefficient (Rs).Results: Twenty-eight AIH pediatric patients were enrolled, 21 were female and 22 had AIH type 1. Following the cut-off of 6.45 kPa in TLE, 20 patients (71%) were included in group 1, and 8 in group 2. A statistically significant difference was found between the two groups on APRI and FIB-4 results (P=0.0306 and P=0.0055, respectively). There was a significant correlation between TLE with APRI and FIB-4 (Rs=0.67 and 0.78, respectively; P<0.01) as well as with platelet count (Rs=-0.68; P<0.01).Conclusion: APRI, FIB-4 and Platelet Count showed a good and positive correlation with transient liver elastography in pediatric patients with AIH.","PeriodicalId":35671,"journal":{"name":"Arquivos de Gastroenterologia","volume":"61 ","pages":"e24047"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arquivos de Gastroenterologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/S0004-2803.24612024-047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: There is limited evidence focusing on the use of non-invasive markers to assess liver fibrosis in pediatric chronic liver diseases.

Objective: The aim of the study was to evaluate the correlation between liver stiffness measurement (LSM) using transient liver elastography (TLE) and serum non-invasive markers in pediatric autoimmune hepatitis (AIH).

Methods: Cross-sectional study between May 2016 and February 2020. Twenty-eight children with AIH (age range between 3 and 20 years old) who had undergone TLE and had routine serum tests were enrolled. Patients were divided into 2 groups: (1) Liver fibrosis degree ≥F2 (TLE ≥6.45 kPa) and (2)

Results: Twenty-eight AIH pediatric patients were enrolled, 21 were female and 22 had AIH type 1. Following the cut-off of 6.45 kPa in TLE, 20 patients (71%) were included in group 1, and 8 in group 2. A statistically significant difference was found between the two groups on APRI and FIB-4 results (P=0.0306 and P=0.0055, respectively). There was a significant correlation between TLE with APRI and FIB-4 (Rs=0.67 and 0.78, respectively; P<0.01) as well as with platelet count (Rs=-0.68; P<0.01).

Conclusion: APRI, FIB-4 and Platelet Count showed a good and positive correlation with transient liver elastography in pediatric patients with AIH.

查看原文本刊更多论文

在小儿自身免疫性肝炎中，肝脏硬度测量与 Apri、Fib-4 和血小板计数之间存在良好的相关性。

背景：由于肝脏活检具有侵入性，人们对使用非侵入性肝脏纤维化标记物越来越感兴趣：-由于肝活检的侵入性，人们对使用非侵入性肝脏纤维化标志物的兴趣日益浓厚：背景：APRI、FIB-4和血小板计数与肝僵化之间存在明显的正相关：小儿自身免疫性肝炎患者的FIB-4和血小板计数以及瞬时弹性成像评估的肝脏硬度测量：使用无创标记物评估小儿慢性肝病肝纤维化的证据有限：本研究旨在评估小儿自身免疫性肝炎（AIH）中使用瞬态肝脏弹性成像（TLE）测量肝脏硬度（LSM）与血清无创标志物之间的相关性：2016年5月至2020年2月期间的横断面研究。共纳入 28 名接受过 TLE 和常规血清检测的 AIH 患儿（年龄在 3 至 20 岁之间）。患者分为两组：（1）肝纤维化程度≥F2（TLE≥6.45 kPa）；（2）结果：28例AIH儿科患者中，21例为女性，22例为AIH 1型。根据 TLE 6.45 kPa 临界值，20 名患者（71%）被纳入第一组，8 名被纳入第二组。两组患者的 APRI 和 FIB-4 结果差异有统计学意义（分别为 P=0.0306 和 P=0.0055）。TLE与APRI和FIB-4之间存在明显的相关性（Rs分别为0.67和0.78；PC结论：在AIH儿科患者中，APRI、FIB-4和血小板计数与瞬时肝弹性成像呈良好的正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.