Spatial Similarity of MRI-Visible Perivascular Spaces in Healthy Young Adult Twins.

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Yonsei Medical Journal Pub Date : 2024-11-01 DOI:10.3349/ymj.2023.0581

Boeun Lee, Na-Young Shin, Chang-Hyun Park, Yoonho Nam, Soo Mee Lim, Kook Jin Ahn

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引用次数: 0

Abstract

Purpose: This study aimed to determine whether genetic factors affect the location of dilated perivascular spaces (dPVS) by comparing healthy young twins and non-twin (NT) siblings.

Materials and methods: A total of 700 healthy young adult twins and NT siblings [138 monozygotic (MZ) twin pairs, 79 dizygotic (DZ) twin pairs, and 133 NT sibling pairs] were collected from the Human Connectome Project dataset. dPVS was automatically segmented and normalized to standard space. Then, spatial similarity indices [mean squared error (MSE), structural similarity (SSIM), and dice similarity (DS)] were calculated for dPVS in the basal ganglia (BGdPVS) and white matter (WMdPVS) between paired subjects before and after propensity score matching of dPVS volumes between groups. Within-pair correlations for the regional volumes of dVPS were also assessed using the intraclass correlation coefficient.

Results: The spatial similarity of dPVS was significantly higher in MZ twins [higher DS (median, 0.382 and 0.310) and SSIM (0.963 and 0.887) and lower MSE (0.005 and 0.005) for BGdPVS and WMdPVS, respectively] than in DZ twins [DS (0.121 and 0.119), SSIM (0.941 and 0.868), and MSE (0.010 and 0.011)] and NT siblings [DS (0.106 and 0.097), SSIM (0.924 and 0.848), and MSE (0.016 and 0.017)]. No significant difference was found between DZ twins and NT siblings. Similar results were found even after the subjects were matched according to dPVS volume. Regional dPVS volumes were also more correlated within pairs in MZ twins than in DZ twins and NT siblings.

Conclusion: Our results suggest that genetic factors affect the location of dPVS.

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健康青壮年双胞胎核磁共振成像可见血管周围空间的空间相似性

目的：本研究旨在通过比较健康的年轻双胞胎和非双胞胎（NT）兄弟姐妹，确定遗传因素是否会影响血管周围间隙扩张（dPVS）的位置：从人类连接组计划数据集中收集了700对健康的年轻成人双胞胎和NT兄弟姐妹（138对单卵双生（MZ）双胞胎、79对双卵双生（DZ）双胞胎和133对NT兄弟姐妹）。然后，计算配对受试者之间基底节（BGdPVS）和白质（WMdPVS）dPVS 的空间相似性指数[均方误差（MSE）、结构相似性（SSIM）和骰子相似性（DS）]。还使用类内相关系数评估了配对受试者之间 dVPS 区域体积的相关性：结果：MZ 双胞胎的 dPVS 空间相似性明显更高[DS（中位数，0.382 和 0.310）和 SSIM（0.963 和 0.887）更高，BGdPVS 的 MSE（0.005 和 0.与 DZ 双胞胎[DS（0.121 和 0.119）、SSIM（0.941 和 0.868）和 MSE（0.010 和 0.011）]和 NT 兄弟姐妹[DS（0.106 和 0.097）、SSIM（0.924 和 0.848）和 MSE（0.016 和 0.017）]相比，BGdPVS 和 WMdPVS 的 DS（中位数）和 SSIM（0.382 和 0.310）较高，MSE（0.005 和 0.005）较低。DZ双胞胎和NT兄弟姐妹之间没有发现明显差异。根据 dPVS 体积对受试者进行配对后也发现了类似的结果。与 DZ 双胞胎和 NT 兄弟姐妹相比，MZ 双胞胎的区域 dPVS 体积在配对内的相关性也更高：我们的研究结果表明，遗传因素会影响 dPVS 的位置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Yonsei Medical Journal 医学-医学：内科

CiteScore

4.50

自引率

0.00%

发文量

167

审稿时长

3 months

期刊介绍： The goal of the Yonsei Medical Journal (YMJ) is to publish high quality manuscripts dedicated to clinical or basic research. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, case reports, brief communications, and letters to the Editor.