Comparative outcomes of Living Donor Liver Transplantation in elderly recipients: A study on morbidity and survival in 1,018 recipients.

IF 4.7 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Liver Transplantation Pub Date : 2024-10-25 DOI:10.1097/LVT.0000000000000518

Fuat Saner, Dimitri A Raptis, Leen Alchibi, Sami A Kareem, Kris Ann H Marquez, Yasser Elsheikh, Yasir Alnemary, Saleh Alabbad, Markus U Boehnert, Massimo Malago, Dieter C Broering

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引用次数: 0

Abstract

Background and aims: Given the increasing demand of patients requiring liver transplant who are 70 years or older and have may have health conditions, this study aimed to assess the outcomes of Living Donor Liver Transplant (LDLT) recipients, in this age group.

Methods: We conducted an analysis using a prospective registry that included all LDLT recipients from January 2011 to May 2023. Patients into two age groups; 18-69 years and 70 years or older and compared their short- term and long-term outcomes. We considered complications as major if they were Grade ≥3a (Dindo-Clavian).

Results: Among 1018 LDLT recipients, 71 (7%) were aged 70 years or older. The rates of post-transplant complications of any severity were comparable between the younger and older age groups (467% vs. 46%, p =0.983), as were the rates of major complications (25% vs. 25%, p =0.995) and in-hospital mortality (6% vs. 7%, p =0.800). The 1-, 3-, and 5-year graft survival rates were 94%, 86%, and 81% in the younger group and 92%, 87%, and 65% in the older group ( p =0.090). Similarly, the overall 1-, 3-, and 5-year recipient survival rates were 90%, 85%, and 86% in the younger group and 88%, 86%, and 65% in the older group ( p =0.100).

Conclusion: This study suggests that carefully selected elderly patients can undergo LDLT and achieve comparable short-term outcomes to their younger counterparts.

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老年受者活体肝移植的比较结果：关于 1,018 名受者发病率和存活率的研究。

背景和目的：鉴于需要肝移植的 70 岁或 70 岁以上且可能有健康问题的患者越来越多，本研究旨在评估该年龄组活体肝移植（LDLT）受者的预后：我们使用前瞻性登记系统进行了分析，该系统包括 2011 年 1 月至 2023 年 5 月期间的所有 LDLT 受者。我们将患者分为两个年龄组：18-69 岁和 70 岁或以上，并比较了他们的短期和长期预后。如果并发症≥3a级（Dindo-Clavian），我们将其视为主要并发症：在 1018 名 LDLT 受者中，有 71 人（7%）年龄在 70 岁或以上。年轻组和老年组的移植后任何严重程度并发症发生率相当（467% 对 46%，P=0.983），主要并发症发生率（25% 对 25%，P=0.995）和院内死亡率（6% 对 7%，P=0.800）也相当。年轻组的1年、3年和5年移植物存活率分别为94%、86%和81%，年长组分别为92%、87%和65%（P=0.090）。同样，年轻组受者的1年、3年和5年总存活率分别为90%、85%和86%，老年组分别为88%、86%和65%（P=0.100）：本研究表明，经过精心挑选的老年患者可以接受 LDLT，并获得与年轻患者相当的短期疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Liver Transplantation 医学-外科

CiteScore

7.40

自引率

6.50%

发文量

254

审稿时长

3-8 weeks

期刊介绍： Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD, Liver Transplantation delivers current, peer-reviewed articles on liver transplantation, liver surgery, and chronic liver disease — the information necessary to keep abreast of this evolving specialty.