Microscope-enabled Disc Dissolution System: Concordance between drug and polymer dissolution from an amorphous solid dispersion disc and visual disc degradation.

IF 3.7 3区 医学 Q2 CHEMISTRY, MEDICINAL
Shuaiqian Men, James E Polli
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引用次数: 0

Abstract

A microscopic erosion time test was recently described to anticipate amorphous solid dispersion (ASD) drug load dispersibility limit, using 0.5ml media volume. Studies here build upon this microscope-enabled method but focus on drug and polymer dissolution from an ASD disc, along with imaging. The objective was 1) to design and build a microscope-enabled disc dissolution system (MeDDiS) with a 900mL dissolution volume and 2) assess the ability of MeDDiS imaging of dissolving discs to provide concordance with measured drug and polymer dissolution profiles. MeDDiS employed a digital microscope to image ASD discs and a one-liter vessel for dissolution. ASD discs containing ritonavir (5-50% drug load) and PVPVA were fabricated and subjected to in vitro dissolution using MeDDiS, where disc diameter was quantified with time. Ritonavir and PVPVA release were also measured. Results indicate concordance between imaging and dissolution. Both found 25% drug load to provide high drug and polymer release, but 30% yielded low release. Quantitatively, MeDDiS images predicted drug and polymer release profile, both above and below the drug load cliff. Overall, studies here describe a MeDDiS which has promised to anticipate drug and polymer dissolution, via imaging of dissolving discs, above and below the ASD drug load cliff.

显微镜驱动的圆片溶解系统:无定形固体分散盘中药物和聚合物的溶解与目视盘降解之间的一致性。
最近介绍了一种显微侵蚀时间测试方法,用于预测无定形固体分散体(ASD)的药物负载分散极限,使用的介质体积为 0.5 毫升。此处的研究以这种显微镜辅助方法为基础,但重点关注药物和聚合物从 ASD 盘中的溶解以及成像。研究的目的是:1)设计和构建一个溶解容量为 900 毫升的显微镜辅助圆片溶解系统(MeDDiS);2)评估 MeDDiS 对溶解圆片成像的能力,使其与测量的药物和聚合物溶解曲线保持一致。MeDDiS 使用数码显微镜对 ASD 盘和一升容器进行溶解成像。制作了含有利托那韦(5-50% 药物负载)和 PVPVA 的 ASD 圆片,并使用 MeDDiS 对其进行体外溶解,圆片直径随时间变化进行量化。同时还测量了利托那韦和 PVPVA 的释放量。结果表明成像和溶出之间是一致的。两者都发现 25% 的药物负荷可提供较高的药物和聚合物释放量,但 30% 的释放量较低。从定量角度来看,MeDDiS 图像预测了药物和聚合物的释放情况,无论是高于还是低于载药悬崖。总之,本文的研究描述了一种 MeDDiS,它有望通过对溶解盘的成像,预测 ASD 药物载量悬崖上下的药物和聚合物溶解情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.30
自引率
13.20%
发文量
367
审稿时长
33 days
期刊介绍: The Journal of Pharmaceutical Sciences will publish original research papers, original research notes, invited topical reviews (including Minireviews), and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.
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