Sex- and age-dependent impacts of nicotine and ethanol binge drinking on the brain: Insights from preclinical research.

IF 4.2 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Stella J Farias Cardozo, Andrew J Lawrence, Roberta Goncalves Anversa
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引用次数: 0

Abstract

Electronic cigarette use among adolescents is a growing concern, not only due to the high incidence of co-use with other substances, such as alcohol, but also due to the fact brain is still maturing during this period. Combined exposure to alcohol and nicotine leads to plastic adaptation of crucial circuits in the brain, which can contribute to the development of addiction. It is well established that nicotine exposure can facilitate alcohol binge drinking, and vice-versa, in a sex-, age- and exposure-dependent manner. Nonetheless, the central mechanisms underlying the synergistic relationship between these two substances and the emergence of differential behavioural traits dependent on these factors remain underexplored. Preclinical studies continue to provide valuable insights into such mechanisms. Here, we discuss recent preclinical findings that report behavioural changes characteristic of addiction following nicotine consumption, primarily in models of vaping and alcohol use; and insights into the neural mechanisms impacted by intake of these two substances, with a focus on the adolescent brain.

尼古丁和乙醇暴饮对大脑的影响与性别和年龄有关:临床前研究的启示。
青少年使用电子香烟的问题日益受到关注,这不仅是因为青少年与酒精等其他物质同时使用电子香烟的比例很高,还因为在这一时期大脑仍在发育成熟。同时接触酒精和尼古丁会导致大脑关键回路的可塑性适应,从而导致成瘾的产生。众所周知,尼古丁接触会促进酒精暴饮,反之亦然,这与性别、年龄和接触方式有关。然而,这两种物质之间的协同关系以及依赖于这些因素而出现的不同行为特征的核心机制仍未得到充分探索。临床前研究继续为这些机制提供有价值的见解。在此,我们将讨论最近的临床前研究结果,这些结果报告了尼古丁摄入后成瘾所特有的行为变化,主要是在吸食和使用酒精的模型中;以及对摄入这两种物质所影响的神经机制的见解,重点是青少年大脑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Neurochemistry
Journal of Neurochemistry 医学-神经科学
CiteScore
9.30
自引率
2.10%
发文量
181
审稿时长
2.2 months
期刊介绍: Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.
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