Susceptibility testing of Mycobacterium tuberculosis to pyrazinamide.

Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology Pub Date : 1987-07-01

M Salfinger, F M Kafader

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Abstract

One hundred and sixty clinical isolates of Mycobacterium tuberculois were tested for their sensitivity to pyrazinamide (PZA) using the conventional proportion method (Middlebrook 7H10 agar) and the results compared to the pyrazinamidase (PZase) activity of the strains. The correlation between strains susceptible to PZA and the production of PZase was 99%. None of the isolates were exclusively resistant to PZA. At present the rate of initial PZA resistance in Kanton Zurich is 0.6%.

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结核分枝杆菌对吡嗪酰胺的药敏试验。

采用传统比例法(Middlebrook 7H10琼脂)对160株结核分枝杆菌临床分离株进行了吡嗪酰胺(PZA)敏感性试验，并与菌株的吡嗪酰胺酶(PZase)活性进行了比较。PZA敏感菌株与PZase产量的相关性为99%。没有一个分离株对PZA具有完全抗性。目前，苏黎世坎顿的PZA初始耐药性为0.6%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology

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