A New Multi-mode, High Pressure Portable Transcranial Ultrasound Stimulation System.

IF 4.4 2区医学 Q2 ENGINEERING, BIOMEDICAL

IEEE Transactions on Biomedical Engineering Pub Date : 2024-10-25 DOI:10.1109/TBME.2024.3486748

Zhiwei Li, Zhengxuan Zhou, Xiaoyu Zhang, Yulin Wang, Hanwen Wang, Yingwei Li, Xiaoli Li

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引用次数: 0

Abstract

Objective: Transcranial ultrasound stimulation (TUS) is a promising non-invasive neuromodulation method for brain disorders. Commonly-used TUS systems in research include custom-built and commercial devices. Custom-built devices typically consist of traditional function generator, power amplifier, and ultrasound transducer. Due to cumbersome wiring and absence of dedicated control software, the operation of these devices is inconvenient. Commercial devices often have limited waveform modes and cannot perform ultrasound modulation with complex waveforms. These limitations limit the application of TUS technology by ordinary users. Therefore, we propose a portable TUS system with multiple modes and high acoustic pressure.

Methods: The proposed portable TUS system utilizes a high-power multi-mode stimulator, and an ultrasound transducer with impedance matching module to achieve multiple modes and high acoustic pressure ultrasound neuromodulation.

Results: The stimulator can output four types of waveforms: continuous pulse continuous stimulus (CPCS), intermittent pulse continuous stimulus (IPCS), continuous pulse intermittent stimulus (CPIS), and intermittent pulse intermittent stimulus (IPIS). When using a same transducer, it generates a peak negative pressure that is nearly identical to one produced by a commercial device. And compared to commercial transducer, the peak negative pressure of our transducer is significantly higher, reaching a maximum of 0.95 MPa.

Conclusion: In-vitro experiments were conducted using rat hippocampal brain slices. The experimental results demonstrated the effectiveness of the TUS system for neural stimulation.

Significance: It offers a design method of a portable multi-mode, high pressure TUS system, which is used for complex neural modulation research.

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新型多模式、高压便携式经颅超声波刺激系统

目的：经颅超声刺激（TUS）是一种治疗脑部疾病的前景广阔的非侵入性神经调节方法。研究中常用的 TUS 系统包括定制设备和商用设备。定制设备通常由传统的函数发生器、功率放大器和超声换能器组成。由于接线繁琐且没有专用的控制软件，这些设备的操作很不方便。商用设备通常只有有限的波形模式，无法进行复杂波形的超声调制。这些局限性限制了普通用户对 TUS 技术的应用。因此，我们提出了一种具有多种模式和高声压的便携式 TUS 系统：方法：所提出的便携式 TUS 系统利用大功率多模式刺激器和带阻抗匹配模块的超声换能器来实现多模式和高声压超声神经调制：该刺激器可输出四种波形：连续脉冲连续刺激（CPCS）、间歇脉冲连续刺激（IPCS）、连续脉冲间歇刺激（CPIS）和间歇脉冲间歇刺激（IPIS）。当使用相同的传感器时，它产生的负压峰值与商用设备产生的负压峰值几乎相同。与商用传感器相比，我们的传感器产生的峰值负压明显更高，最大可达 0.95 兆帕：结论：我们使用大鼠海马脑片进行了体外实验。实验结果证明了 TUS 系统对神经刺激的有效性：意义：提供了一种用于复杂神经调控研究的便携式多模式高压 TUS 系统的设计方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Transactions on Biomedical Engineering 工程技术-工程：生物医学

CiteScore

9.40

自引率

4.30%

发文量

880

审稿时长

2.5 months

期刊介绍： IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. Papers range from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations with engineering contributions.