Multi-task Adaptive Resolution Network for Lymph Node Metastasis Diagnosis from Whole Slide Images of Colorectal Cancer.

Abstract

Automated detection of lymph node metastasis (LNM) holds great potential to alleviate the workload of doctors and reduce misinterpretations. Despite the practical successes achieved, effectively addressing the highly complex and heterogeneous tumor microenvironment remains an open and challenging problem, especially when tumor subtypes intermingle and are difficult to delineate. In this paper, we propose a multi-task adaptive resolution network, named MAR-Net, for LNM detection and subtyping in complex mixed-type cancers. Specifically, we construct a resolution-aware module to mine heterogeneous diagnostic information, which exploits the multi-scale pyramid information and adaptively combines multi-resolution structured features for comprehensive representation. Additionally, we adopt a multi-task learning approach that simultaneously addresses LNM detection and subtyping, reducing model instability during optimization and improving performance across both tasks. More importantly, to rectify the potential misclassification of tumor subtypes, we elaborately design a hierarchical subtying refinement (HSR) algorithm that leverages a generic segmentation model informed by pathologists' prior knowledge. Evaluations have been conducted on three private and one public cancer datasets (554 WSIs, 4.8 million patches). Our experimental results demonstrate that the proposed method consistently achieves superior performance compared to the state-of-the-art methods, achieving 0.5% to 3.2% higher AUC in LNM detection and 3.8% to 4.4% higher AUC in LNM subtyping.