Impact of irrigation flow rates on lesion size and safety of ablation catheters: an ex vivo porcine heart study.

Abstract

Radiofrequency (RF) catheter ablation is a well-established therapeutic approach for treating arrhythmias, where lesion size and safety are critical for efficacy. This study explored the impact of varying irrigation flow rates on lesion characteristics using the TactiFlex™ SE Ablation Catheter (TF) in an ex vivo porcine heart model, focusing on the size and safety outcomes associated with low versus standard flow rates. Myocardial slabs from porcine hearts were subjected to ablation using two types of irrigated catheters. Lesion formation was compared between low (8 mL/min for TF) and standard irrigation flow rates (13 mL/min for TF) across different power settings (30, 40, and 50 W). Outcome measures included lesion dimensions, incidence of steam pops, and impedance drops. A total of 210 lesions were generated under various settings. At low flow rates, the TF catheter safely formed larger lesions compared to the standard flow rates without a significant increase in steam pops or impedance drops. Lesions at low flow rates were comparable in size to those formed using other catheters under the standard settings. Conversely, the standard flow settings for TF produced smaller lesions but exhibited higher safety profiles, as evidenced by fewer steam pops and impedance drops. Lower irrigation flow rates using a TF catheter can achieve larger lesions without compromising safety, offering an optimization strategy for RF ablation procedures that balances efficacy and safety. These findings may guide clinicians in tailoring ablation strategies according to individual patient needs.