Deprivation of visual input alters specific subset of inhibitory neurons and affect thalamic afferent terminals in V1 of rd1 mouse.

IF 4.2 3区 医学 Q2 NEUROSCIENCES
Frontiers in Cellular Neuroscience Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI:10.3389/fncel.2024.1422613
Kashish Parnami, Anushka Surana, Vineet Choudhary, Anwesha Bhattacharyya
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Abstract

Retinitis Pigmentosa (RP) is a heterogenous group of inherited disorder, and its progression not only affects the retina but also the primary visual cortex. This manifests imbalances in the excitatory and inhibitory neurotransmission. Here, we investigated if changes in cortical functioning is linked to alterations in GABAergic population of neurons and its two important subsets, somatostatin (SST) and parvalbumin (PV) neuron in rd1 model of retinal degeneration (RD). We demonstrate marked decrease in the proportion of SST neurons in different layers of cortex whereas PV neurons were less affected. Moreover, we found reduced expression of glutamatergic thalamic afferents (VGLUT2) due to lack of visual activity. These results suggest PV neurons are likely recruited by the cortical circuitry to increase the inhibitory drive and compensate the disrupted inhibition-excitation balance. However, reduced SST expression perhaps results in weakening of stimulus selectivity. Delineating their functional role during RD will provide insights for acquisition of high-resolution vision thereby improving current state of vision restoration.

剥夺视觉输入会改变rd1小鼠V1中特定抑制神经元亚群并影响丘脑传入终端
视网膜色素变性(RP)是一种异质性遗传性疾病,其发展不仅影响视网膜,还影响初级视觉皮层。这表现为兴奋性和抑制性神经传递失衡。在此,我们研究了在视网膜变性(RD)的 rd1 模型中,皮层功能的变化是否与 GABA 能神经元群及其两个重要亚群--体视蛋白(SST)和副视蛋白(PV)神经元--的改变有关。我们发现在大脑皮层的不同层中,SST 神经元的比例明显下降,而 PV 神经元受到的影响较小。此外,我们还发现由于缺乏视觉活动,丘脑谷氨酸能传入神经元(VGLUT2)的表达减少。这些结果表明,视皮层神经元很可能被大脑皮层电路招募,以增加抑制驱动力,补偿被破坏的抑制-兴奋平衡。然而,SST 表达的减少可能会导致刺激选择性的减弱。阐明它们在 RD 期间的功能作用将为获得高分辨率视觉提供启示,从而改善目前的视觉恢复状况。
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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