Targeting PTEN in ischemic stroke: From molecular mechanisms to therapeutic potentials

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2024-10-24 DOI:10.1016/j.expneurol.2024.115023

Yane Zheng , Huiying Gu , Yuming Kong

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引用次数: 0

Abstract

Ischemic stroke remains a leading cause of mortality and disability worldwide, driven by complex pathophysiological mechanisms, including excitotoxicity, oxidative stress, apoptosis, and neuroinflammation. PTEN (Phosphatase and tensin homolog deleted on chromosome 10) plays a crucial role in these processes, influencing key signaling pathways such as PI3K/Akt and mTOR. This review aims to explore PTEN's multifaceted functions in ischemic stroke, examining its interactions with non-coding RNAs, involvement in mitophagy and immune suppression, and overall impact on cellular homeostasis. We will investigate various therapeutic strategies targeting PTEN, including synthetic drugs, natural products, and exosome-based therapies enriched with specific miRNAs. Additionally, we will assess the potential of non-pharmaceutical interventions such as electroacupuncture, exercise, transcranial direct current stimulation (tDCS), and therapeutic hypothermia in modulating PTEN activity to enhance cererbroprotection and functional recovery. By elucidating these aspects, this review aims to inspire and motivate the audience in their research and clinical practice, highlighting PTEN as a promising therapeutic target and paving the way for developing effective treatments for ischemic stroke.

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针对缺血性中风的 PTEN：从分子机制到治疗潜力。

缺血性中风仍然是全球死亡和残疾的主要原因，其病理生理机制复杂，包括兴奋毒性、氧化应激、细胞凋亡和神经炎症。PTEN（10 号染色体上删除的磷酸酶和天丝同源物）在这些过程中发挥着关键作用，影响着 PI3K/Akt 和 mTOR 等关键信号通路。本综述旨在探讨 PTEN 在缺血性中风中的多方面功能，研究其与非编码 RNA 的相互作用、参与有丝分裂和免疫抑制以及对细胞稳态的总体影响。我们将研究针对 PTEN 的各种治疗策略，包括合成药物、天然产品和富含特定 miRNA 的外泌体疗法。此外，我们还将评估电针、运动、经颅直流电刺激（tDCS）和治疗性低温等非药物干预措施在调节 PTEN 活性以增强神经保护和功能恢复方面的潜力。通过阐明这些方面，本综述旨在启发和激励读者的研究和临床实践，突出 PTEN 作为一个有前景的治疗靶点，为开发缺血性卒中的有效治疗方法铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.