Clinical characteristics of patients with eosinophilic esophagitis and eosinophilic esophageal myositis based on esophageal motility.

IF 2.2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Esophagus Pub Date : 2024-10-22 DOI:10.1007/s10388-024-01093-5

Noriyuki Kawami, Yoshimasa Hoshikawa, Eri Momma, Tomohide Tanabe, Mai Koeda, Shintaro Hoshino, Katsuhiko Iwakiri

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引用次数: 0

Abstract

Background: Eosinophilic esophagitis (EoE) presents with various esophageal motility disorders, and some cases of hypercontractile esophagus (HE) are associated with eosinophilic esophageal myositis (EoEM). This study aimed to compare the clinical characteristics of patients with EoE and EoEM according to their esophageal motility.

Methods: The 28 patients with EoE and 2 patients with EoEM were divided into three groups based on esophageal motility: normal motility group, hypomotility group, and spastic contraction group. The clinical characteristics of the three groups were retrospectively compared.

Results: Among the 28 patients with EoE, there were 15 with normal esophageal motility, 9 with hypomotility (2 with absent contractility, 7 with ineffective esophageal motility), and 4 with spastic contractions (1 with type III achalasia, 1 with HE, 2 with unclassifiable multipeak contractions). The two patients with EoEM had HE. Most patients in the normal and hypomotility groups had typical endoscopic findings of EoE, whereas these typical findings were less common in the spastic contraction group (P < 0.001). Four of the five patients with esophageal stricture were in the hypomotility group (P = 0.036). The therapy method significantly differed between the three groups: the normal group had more patients that responded to a proton pump inhibitor or potassium-competitive acid blocker, the hypomotility group had more patients that responded to steroids, and the spastic contraction group contained two patients treated with per-oral endoscopic myotomy (P = 0.021).

Conclusions: The endoscopic findings and therapy methods differ between patients with EoE and EoEM based on the esophageal motility.

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基于食管运动的嗜酸性粒细胞食管炎和嗜酸性粒细胞食管肌炎患者的临床特征。

背景：嗜酸性粒细胞食管炎（EoE）伴有各种食管运动障碍，一些食管过度收缩（HE）病例与嗜酸性粒细胞食管肌炎（EoEM）相关。本研究旨在根据食管运动情况比较食管炎和食管肌炎患者的临床特征：根据食管运动能力将28名EoE患者和2名EoEM患者分为三组：正常运动组、低运动组和痉挛性收缩组。回顾性比较了三组患者的临床特征：结果：在28名食管水肿患者中，15人食管运动正常，9人运动减弱（2人无收缩力，7人食管运动无效），4人痉挛性收缩（1人III型贲门失弛缓症，1人HE，2人无法分类的多峰收缩）。两名 EoEM 患者患有高频收缩。正常组和运动减弱组的大多数患者都有典型的食道炎内镜检查结果，而这些典型检查结果在痉挛性收缩组较少见（P < 0.001）。五名食管狭窄患者中有四名属于运动减弱组（P = 0.036）。三组患者的治疗方法存在明显差异：正常组中对质子泵抑制剂或钾竞争性酸阻滞剂有反应的患者较多，肌张力减低组中对类固醇有反应的患者较多，而痉挛性收缩组中有两名患者接受了经口内镜肌切开术治疗（P = 0.021）：结论：根据食管运动情况，EoE 和 EoEM 患者的内镜检查结果和治疗方法有所不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Esophagus GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

>12 weeks

期刊介绍： Esophagus, the official journal of the Japan Esophageal Society, introduces practitioners and researchers to significant studies in the fields of benign and malignant diseases of the esophagus. The journal welcomes original articles, review articles, and short articles including technical notes ( How I do it ), which will be peer-reviewed by the editorial board. Letters to the editor are also welcome. Special articles on esophageal diseases will be provided by the editorial board, and proceedings of symposia and workshops will be included in special issues for the Annual Congress of the Society.