New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play?

IF 3 4区 医学 Q2 ALLERGY
Chen-Chung Lin, Brandon F Law, Justin M Hettick
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引用次数: 0

Abstract

Purpose of review: To describe recent findings of diisocyanate-mediated mechanisms in allergy and toxicology by addressing the role of microRNA (miR) in immune responses that may contribute to the development of occupational asthma (OA).

Recent findings: Studies of diisocyanate asthma have traditionally focused on the immune and inflammatory patterns associated with diisocyanate exposures; however, recognized knowledge gaps exist regarding the detailed molecular mechanism(s) of pathogenesis. Recent studies demonstrate the critical role endogenous microRNAs play as gene regulators in maintaining homeostasis of the human body, and in the pathophysiology of many diseases including asthma. Given that diisocyanate-OA shares many pathophysiological characteristics with asthma, it is likely that miR-mediated mechanisms are involved in the pathophysiology of diisocyanate-OA. Recent reports have shown that changes in expression of endogenous miRs are associated with exposure to the occupationally relevant diisocyanates, toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). Continued mechanistic study of these relevant miRs may lead to the development of novel biomarkers of occupational exposure and/or provide efficacious targets for therapeutic strategies in diisocyanate asthma.

Summary: The molecular mechanisms underlying diisocyanate-OA pathophysiology are heterogeneous and complicated. In this review, we highlight recent research into the roles and potential regulation of miRs in diisocyanate-OA.

二异氰酸酯介导的过敏/毒性的新机制:microRNA 在起作用吗?
综述目的:通过探讨微 RNA(miR)在可能导致职业性哮喘(OA)发生的免疫反应中的作用,描述过敏症和毒理学中二异氰酸酯介导机制的最新发现:对二异氰酸酯哮喘的研究历来侧重于与二异氰酸酯接触相关的免疫和炎症模式;然而,在发病的详细分子机制方面存在公认的知识差距。最近的研究表明,内源性 microRNA 作为基因调控因子在维持人体平衡和包括哮喘在内的许多疾病的病理生理学中发挥着关键作用。鉴于二异氰酸酯-OA 与哮喘有许多共同的病理生理学特征,miR 介导的机制很可能参与了二异氰酸酯-OA 的病理生理学。最近的报告显示,内源性 miRs 表达的变化与暴露于职业相关的二异氰酸酯、甲苯二异氰酸酯(TDI)和亚甲基二苯基二异氰酸酯(MDI)有关。继续对这些相关 miRs 进行机理研究,可能会开发出职业暴露的新型生物标志物,并/或为二异氰酸酯哮喘的治疗策略提供有效的靶点。在这篇综述中,我们将重点介绍 miRs 在二异氰酸酯哮喘中的作用和潜在调控的最新研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
3.60%
发文量
109
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.
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