Public Acceptance of Living Donor Liver Transplant for Colorectal Liver Metastases: A Web-Based Survey

IF 1.9 4区医学 Q2 SURGERY

Clinical Transplantation Pub Date : 2024-10-26 DOI:10.1111/ctr.70013

Mariana Chávez-Villa, Elizabeth Pope-Collins, Katherine Dokus, John Martens, Elizabeth Keller, Mark Nickels, Matthew Byrne, Roberto Hernandez-Alejandro, Bandar Al-Judaibi

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引用次数: 0

Abstract

Background

Recent advancements in cancer treatment and post-transplant management have expanded the population of living donor liver transplant (LDLT) candidates. We aimed to examine variations in public acceptance of LDLT based on patient diagnosis, including unresectable colorectal liver metastases (uCRLM).

Methods

A web-based survey collected demographic information and general perceptions about organ donation in different settings. Respondents indicated their likelihood of being a living liver donor for a family member with genetic liver disease, alcohol-related liver disease (ALD), and uCRLM. Differences in the likelihood of donation between scenarios were compared.

Results

There were 491 survey respondents (female [76.5%], Caucasians [87.4%], and had at least a college degree [98.2%]). Most (82.4%) were aware of the option of living liver donation before the study and 95% supported living organ donation in general. Over 80% were registered as organ donors. Ninety percent indicated that they would be likely to donate to a family member with a genetic liver disease if they qualified as a living donor; significantly more than ALD (59%) and uCRLM (71%) (p < 0.001). Willingness to donate to patients with uCRLM was significantly higher (p < 0.001) than the hypothetical patient with ALD with a clinically accepted recovery period of 6 months.

Conclusions

This study is the first of its kind to assess the public acceptance of living liver donation for uCRLM. Respondents were as or more supportive of donating to uCRLM as they were of generally accepted indications for LT. Further surveys with a broader respondent pool are warranted.

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公众对大肠癌肝转移活体肝移植的接受程度：基于网络的调查。

背景：癌症治疗和移植后管理方面的最新进展扩大了活体肝移植（LDLT）的候选人群。我们旨在根据患者诊断（包括不可切除的结直肠肝转移（uCRLM））研究公众对 LDLT 接受程度的差异：一项基于网络的调查收集了人口统计学信息和对不同环境下器官捐献的一般看法。受访者表示了他们为患有遗传性肝病、酒精相关肝病（ALD）和 uCRLM 的家庭成员捐献活体肝脏的可能性。比较了不同情况下捐献可能性的差异：共有 491 名调查对象（女性 [76.5%]、白种人 [87.4%]、至少有大学学历 [98.2%]）。大多数受访者（82.4%）在调查前知道有活体肝脏捐献这一选择，95%的受访者普遍支持活体器官捐献。超过 80% 的人登记为器官捐献者。90%的人表示，如果他们有资格成为活体肝脏捐献者，他们可能会捐献给患有遗传性肝病的家庭成员；这一比例明显高于 ALD（59%）和 uCRLM（71%）（p < 0.001）。对 uCRLM 患者的捐赠意愿（p < 0.001）明显高于假定的 ALD 患者（临床接受的恢复期为 6 个月）：这项研究首次评估了公众对尿毒症活体肝脏捐献的接受程度。受访者对捐献 uCRLM 的支持程度不亚于或高于一般公认的 LT 适应症。有必要对更广泛的受访者进行进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Transplantation 医学-外科

CiteScore

3.70

自引率

4.80%

发文量

286

审稿时长

2 months

期刊介绍： Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored. Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include: Immunology and immunosuppression; Patient preparation; Social, ethical, and psychological issues; Complications, short- and long-term results; Artificial organs; Donation and preservation of organ and tissue; Translational studies; Advances in tissue typing; Updates on transplant pathology;. Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries. Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.