Effect of Endogenous Hormone Levels on Basal Metabolic Rate in Men With Obesity

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Clinical Endocrinology Pub Date : 2024-10-27 DOI:10.1111/cen.15157

Jolijn Van Cauwenberghe, Kristof Van Dessel, Christophe De Block, Eveline Dirinck

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引用次数: 0

Abstract

Objective

Basal metabolic rate (BMR) is an important factor in weight management and is influenced by fat-free mass (FFM), fat mass (FM) and age. Current knowledge of the influence of hormonal levels on BMR is based on studies with small populations, studies that investigate exogenous administration and studies frequently lacking correction for body composition.

Design

Cross-sectional study.

Patients

All men (n = 457) who were referred to our centre for a metabolic work-up were eligible for inclusion. Median age was 47 (18–78) years and the vast majority had obesity (BMI ≥ 30 kg/m², 90.9%).

Measurements

All men had a measurement of BMR, body composition and measurement of testosterone, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS), insulin-like growth factor 1 (IGF-1), thyroid-stimulating hormone (TSH) and free thyroxine (fT4). Men with low, normal and/or high levels of each of these hormones were compared. The association between hormone levels and BMR was assessed through linear regression models. All analyses were controlled for FFM, FM and age.

Results

In men with obesity, testosterone (total or free) was not associated with BMR. Linear regression analysis showed that DHEAS was positively associated with BMR in a sample of men with obesity and normal endogenous DHEAS levels, with the following equation: BMR (adjusted R² = 0.72): (BMR [kcal/d] = 513.402 + 18.940 × FFM [kg] + 9.507 × FM [kg] − 3.362 × age [years] + 0.307 × DHEAS [µg/dL]) (p < 0.01). TSH, fT4 and IGF-1 were not associated with BMR.

Conclusion

In men with obesity, endogenous DHEAS is positively associated with BMR. Testosterone, TSH, fT4 and IGF-1 were not associated with BMR in men with obesity. Since we examined the specific population of men with obesity and only examined endogenous hormone levels, no extrapolation of results to other populations or the overall population can be made.

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内源性激素水平对肥胖男性基础代谢率的影响

目的：基础代谢率（BMR基础代谢率（BMR）是体重管理的一个重要因素，受无脂质量（FFM）、脂肪质量（FM）和年龄的影响。目前有关荷尔蒙水平对基础代谢率影响的知识都是基于小规模人群的研究、外源性给药研究以及经常缺乏身体成分校正的研究：设计：横断面研究：所有转诊至本中心进行代谢检查的男性（n = 457）均符合纳入条件。年龄中位数为 47（18-78）岁，绝大多数为肥胖（体重指数≥ 30 kg/m²，90.9%）：所有男性都进行了基础代谢率、身体成分和睾酮、性激素结合球蛋白（SHBG）、硫酸脱氢表雄酮（DHEAS）、胰岛素样生长因子 1（IGF-1）、促甲状腺激素（TSH）和游离甲状腺素（fT4）的测量。对这些激素水平偏低、正常和/或偏高的男性进行了比较。激素水平与基础代谢率之间的关系通过线性回归模型进行评估。所有分析均控制了FFM、FM和年龄：结果：在肥胖男性中，睾酮（总睾酮或游离睾酮）与基础代谢率无关。线性回归分析表明，在肥胖且内源性 DHEAS 水平正常的男性样本中，DHEAS 与 BMR 呈正相关，方程如下：基础代谢率（调整后 R² = 0.72）：(BMR [kcal/d] = 513.402 + 18.940 × FFM [kg] + 9.507 × FM [kg] - 3.362 × 年龄 [岁] + 0.307 × DHEAS [µg/dL])：在肥胖男性中，内源性 DHEAS 与 BMR 呈正相关。在肥胖男性中，睾酮、促甲状腺激素、fT4 和 IGF-1 与 BMR 无关。由于我们研究的是肥胖症男性这一特定人群，而且只研究了内源性激素水平，因此无法将结果推断到其他人群或整体人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Endocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

3.10%

发文量

192

审稿时长

1 months

期刊介绍： Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.