Long non-coding RNA-encoded micropeptides: functions, mechanisms and implications.

IF 6.1 2区 生物学 Q1 CELL BIOLOGY
Yinan Xiao, Yaru Ren, Wenteng Hu, Athanasios R Paliouras, Wenyang Zhang, Linghui Zhong, Kaixin Yang, Li Su, Peng Wang, Yonghong Li, Minjie Ma, Lei Shi
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引用次数: 0

Abstract

Long non-coding RNAs (lncRNAs) are typically described as RNA transcripts exceeding 200 nucleotides in length, which do not code for proteins. Recent advancements in technology, including ribosome RNA sequencing and ribosome nascent-chain complex sequencing, have demonstrated that many lncRNAs retain small open reading frames and can potentially encode micropeptides. Emerging studies have revealed that these micropeptides, rather than lncRNAs themselves, are responsible for vital functions, including but not limited to regulating homeostasis, managing inflammation and the immune system, moderating metabolism, and influencing tumor progression. In this review, we initially outline the rapidly advancing computational analytical methods and public tools to predict and validate the potential encoding of lncRNAs. We then focus on the diverse functions of micropeptides and their underlying mechanisms in the pathogenesis of disease. This review aims to elucidate the functions of lncRNA-encoded micropeptides and explore their potential applications as therapeutic targets in cancer.

长非编码 RNA 编码的微肽:功能、机制和影响。
长非编码 RNA(lncRNA)通常指长度超过 200 个核苷酸的 RNA 转录本,它们不编码蛋白质。最近的技术进步,包括核糖体 RNA 测序和核糖体新生链复合物测序,表明许多 lncRNA 保留了小的开放阅读框,有可能编码微肽。新近的研究发现,这些微肽(而非 lncRNA 本身)具有重要功能,包括但不限于调节体内平衡、管理炎症和免疫系统、调节新陈代谢以及影响肿瘤进展。在这篇综述中,我们首先概述了快速发展的计算分析方法和公共工具,用于预测和验证 lncRNAs 的潜在编码。然后,我们将重点讨论微肽的各种功能及其在疾病发病机制中的潜在机制。本综述旨在阐明lncRNA编码的微肽的功能,并探索它们作为癌症治疗靶点的潜在应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Death Discovery
Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
8.30
自引率
1.40%
发文量
468
审稿时长
9 weeks
期刊介绍: Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.
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