Deciphering the nexus between long non-coding RNAs and endoplasmic reticulum stress in hepatocellular carcinoma: biomarker discovery and therapeutic horizons.

IF 6.1 2区 生物学 Q1 CELL BIOLOGY
Himanshi Goyal, Sachin Parwani, Jyotdeep Kaur
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引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) remains a significant global health challenge with few effective treatment options. The dysregulation of endoplasmic reticulum (ER) stress responses has emerged as a pivotal factor in HCC progression and therapy resistance. Long non-coding RNAs (lncRNAs) play a crucial role as key epigenetic modifiers in this process. Recent research has explored how lncRNAs influence ER stress which in turn affects lncRNAs activity in HCC. We systematically analyze the current literature to highlight the regulatory roles of lncRNAs in modulating ER stress and vice versa in HCC. Our scrutinization highlights how dysregulated lncRNAs contribute to various facets of HCC, including apoptosis resistance, enhanced proliferation, invasion, and metastasis, all driven by ER stress. Moreover, we delve into the emerging paradigm of the lncRNA-miRNA-mRNA axis, elucidating it as the promising avenue for developing novel biomarkers and paving the way for more personalized treatment options in HCC. Nevertheless, we acknowledge the challenges and future directions in translating these insights into clinical practice. In conclusion, our review provides insights into the complex regulatory mechanisms governing ER stress modulation by lncRNAs in HCC.

解密肝细胞癌中长非编码 RNA 与内质网应激之间的关系:生物标记物的发现与治疗前景。
肝细胞癌(HCC)仍然是全球健康面临的重大挑战,但有效的治疗方案却寥寥无几。内质网(ER)应激反应失调已成为导致 HCC 进展和耐药性的关键因素。长非编码 RNA(lncRNA)作为关键的表观遗传修饰因子在这一过程中发挥着至关重要的作用。最近的研究探讨了 lncRNA 如何影响 ER 应激,而 ER 应激又如何影响 lncRNA 在 HCC 中的活性。我们对现有文献进行了系统分析,以突出lncRNAs在HCC中调节ER压力以及反向调节ER压力的作用。我们的研究强调了失调的lncRNA如何导致HCC的各个方面,包括凋亡抵抗、增殖增强、侵袭和转移,所有这些都是由ER压力驱动的。此外,我们还深入研究了lncRNA-miRNA-mRNA轴这一新兴范式,将其阐明为开发新型生物标记物的大有可为的途径,并为HCC中更个性化的治疗方案铺平道路。然而,我们也承认将这些见解转化为临床实践所面临的挑战和未来的方向。总之,我们的综述提供了有关 HCC 中 lncRNAs 调节 ER 应激的复杂调控机制的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Death Discovery
Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
8.30
自引率
1.40%
发文量
468
审稿时长
9 weeks
期刊介绍: Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.
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