Comparison of the anesthetic effects of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery.

IF 2.3 3区医学 Q2 ANESTHESIOLOGY

BMC Anesthesiology Pub Date : 2024-10-23 DOI:10.1186/s12871-024-02773-6

Huan Zhang, Min Fu, Fangli Yue, Yaxin Wei, Xinyuan Shi, Shiyu Yu, Fanceng Ji

{"title":"Comparison of the anesthetic effects of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery.","authors":"Huan Zhang, Min Fu, Fangli Yue, Yaxin Wei, Xinyuan Shi, Shiyu Yu, Fanceng Ji","doi":"10.1186/s12871-024-02773-6","DOIUrl":null,"url":null,"abstract":"Objective: The purpose of this study is to observe whether there is a difference in the anesthetic effect of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery, so as to provide reference for clinical application.Methods: Fifty patients, aged 18-65 years, ASA I-II, scheduled for hysteroscopy under total intravenous anesthesia were selected. The patients were randomly divided into two groups (n = 25): remimazolam tosilate group (group T) and remimazolam besylate group ( group R). The main observation index was the induction dose of remimazolam; secondary observation indicators were sleep time, anesthesia maintenance time, recovery time, induction maintenance dose of alfentanil, maintenance dose of remimazolam, and incidence of adverse events during anesthesia ( hypertension, hypotension, bradycardia, tachycardia).Results: There was no significant difference in anesthesia induction dose, recovery time, sleep time, anesthesia maintenance time, and incidence of adverse events during anesthesia ( body movement, cough, hypertension, hypotension, bradycardia, tachycardia) between the two groups (P > 0.05).Conclusion: There was no significant difference in the anesthetic effect of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery.Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR2400081688.","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"24 1","pages":"382"},"PeriodicalIF":2.3000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515782/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Anesthesiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12871-024-02773-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The purpose of this study is to observe whether there is a difference in the anesthetic effect of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery, so as to provide reference for clinical application.

Methods: Fifty patients, aged 18-65 years, ASA I-II, scheduled for hysteroscopy under total intravenous anesthesia were selected. The patients were randomly divided into two groups (n = 25): remimazolam tosilate group (group T) and remimazolam besylate group ( group R). The main observation index was the induction dose of remimazolam; secondary observation indicators were sleep time, anesthesia maintenance time, recovery time, induction maintenance dose of alfentanil, maintenance dose of remimazolam, and incidence of adverse events during anesthesia ( hypertension, hypotension, bradycardia, tachycardia).

Results: There was no significant difference in anesthesia induction dose, recovery time, sleep time, anesthesia maintenance time, and incidence of adverse events during anesthesia ( body movement, cough, hypertension, hypotension, bradycardia, tachycardia) between the two groups (P > 0.05).

Conclusion: There was no significant difference in the anesthetic effect of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery.

Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR2400081688.

查看原文本刊更多论文

比较托西酸瑞咪唑仑和苯磺酸瑞咪唑仑在日间宫腔镜手术中的麻醉效果。

研究目的本研究旨在观察托西酸瑞咪唑仑和苯磺酸瑞咪唑仑在日间宫腔镜手术中的麻醉效果是否存在差异，从而为临床应用提供参考：方法：选取50例计划在全静脉麻醉下进行宫腔镜手术的患者，年龄18-65岁，ASAⅠ-Ⅱ级。将患者随机分为两组（n = 25）：托昔酸咪唑安定组（T 组）和苯磺酸咪唑安定组（R 组）。主要观察指标为瑞马唑仑诱导剂量，次要观察指标为睡眠时间、麻醉维持时间、恢复时间、阿芬太尼诱导维持剂量、瑞马唑仑维持剂量、麻醉期间不良反应发生率（高血压、低血压、心动过缓、心动过速）：结果：两组在麻醉诱导剂量、恢复时间、睡眠时间、麻醉维持时间以及麻醉期间不良反应（肢体运动、咳嗽、高血压、低血压、心动过缓、心动过速）的发生率方面均无明显差异（P>0.05）：结论：在日间宫腔镜手术中，甲磺酸雷马唑仑和苯磺酸雷马唑仑的麻醉效果无明显差异：临床试验注册：中国临床试验注册中心，ChiCTR2400081688。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Anesthesiology ANESTHESIOLOGY-

CiteScore

3.50

自引率

4.50%

发文量

349

审稿时长

>12 weeks

期刊介绍： BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.