Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders.

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Alexander V Sirotkin, Abdel Halim Harrath
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引用次数: 0

Abstract

Apigenin is an organic flavonoid abundant in some plants such as parsley, chamomile, or celery. Recently, it has been investigated for several of its pharmacological characteristics, such as its ability to act as an antioxidant, reduce inflammation, and inhibit the growth of cancer cells. The purpose of this review is to provide a summary of the existing knowledge regarding the effects of apigenin on female reproductive systems and its dysfunctions. Apigenin can influence reproductive processes by regulating multiple biological events, including oxidative processes, cell proliferation, apoptosis, cell renewal and viability, ovarian blood supply, and the release of reproductive hormones. It could stimulate ovarian folliculogenesis, as well as ovarian and embryonal cell proliferation and viability, which can lead to an increase in fertility and influence the release of reproductive hormones, which may exert its effects on female reproductive health. Furthermore, apigenin could inhibit the activities of ovarian cancer cells and alleviate the pathological changes in the female reproductive system caused by environmental pollutants, harmful medications, cancer, polycystic ovarian syndrome, ischemia, as well as endometriosis. Therefore, apigenin may have potential as a biostimulator for female reproductive processes and as a therapeutic agent for certain reproductive diseases.

芹菜素是一种有望增强女性生殖功能和治疗相关疾病的制剂。
芹菜素是一种有机类黄酮,在欧芹、甘菊或芹菜等植物中含量丰富。最近,人们对芹菜素的一些药理特性进行了研究,如其作为抗氧化剂、减少炎症和抑制癌细胞生长的能力。本综述旨在总结芹菜素对女性生殖系统及其功能障碍的影响方面的现有知识。芹菜素可以通过调节多种生物事件来影响生殖过程,包括氧化过程、细胞增殖、细胞凋亡、细胞更新和活力、卵巢供血和生殖激素的释放。芹菜素可以刺激卵巢卵泡的生成,以及卵巢和胚胎细胞的增殖和活力,从而提高生育能力,并影响生殖激素的释放,对女性生殖健康产生影响。此外,芹菜素还能抑制卵巢癌细胞的活性,缓解环境污染物、有害药物、癌症、多囊卵巢综合征、缺血以及子宫内膜异位症等引起的女性生殖系统病理变化。因此,芹菜素有可能成为女性生殖过程的生物刺激剂和某些生殖疾病的治疗剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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