In silicodosimetry for a prostate cancer treatment using198Au nanoparticles.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Lucas Verdi Angelocci, Sabrina Spigaroli Sgrignoli, Carla Daruich de Souza, Paula Cristina Guimarães Antunes, Maria Elisa Chuery Martins Rostelato, Carlos Alberto Zeituni
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引用次数: 0

Abstract

Objective. To estimate dose rates delivered by using radioactive198Au nanoparticles for prostate cancer nanobrachytherapy, identifying contribution by photons and electrons emmited from the source.Approach. Utilizingin silicomodels, two different anatomical representations were compared: a mathematical model and a unstructured mesh model based on the International Commission on Radiological Protection (ICRP) Publication 145 phantom. Dose rates by activity were calculated to the tumor and nearby healthy tissues, including healthy prostate tissue, urinary bladder wall and rectum, using Monte Carlo code MCNP6.2.Main results. Results indicate that both models provide dose rate estimates within the same order of magnitude, with the mathematical model overestimating doses to the prostate and bladder by approximately 20% compared to the unstructured mesh model. The discrepancies for the tumor and rectum were below 4%. Photons emmited from the source were defined as the primary contributors to dose to other organs, while 97.9% of the dose to the tumor was due to electrons emmited from the source.Significance. Our findings emphasize the importance of model selection in dosimetry, particularly the advantages of using realistic anatomical phantoms for accurate dose calculations. The study demonstrates the feasibility and effectiveness of198Au nanoparticles in achieving high dose concentrations in tumor regions while minimizing exposure to surrounding healthy tissues. Beta emissions were found to be predominantly responsible for tumor dose delivery, reinforcing the potential of198Au nanoparticles in localized radiation therapy. We advocate for using realistic body phantoms in further research to enhance reliability in dosimetry for nanobrachytherapy, as the field still lacks dedicated protocols.

利用 198Au 纳米粒子进行前列腺癌治疗的硅模拟试验。
目标: 估算使用放射性198金纳米粒子进行前列腺癌纳米近距离治疗时的剂量率,确定放射源发射的光子和电子的贡献 方法: 利用硅模型,比较两种不同的解剖表示方法:一种是数学模型,另一种是基于国际放射防护委员会(ICRP)第145号出版物模型的非结构化网格模型。使用蒙特卡罗代码 MCNP6.2,按放射性活度计算了肿瘤和附近健康组织(包括健康的前列腺组织、膀胱壁和直肠)的剂量率。 主要结果: 结果表明,两种模型提供的剂量率估计值在同一数量级内,与非结构化网格模型相比,数学模型高估了前列腺和膀胱约 20% 的剂量。肿瘤和直肠的差异低于 4%。光源发射的光子被定义为其他器官剂量的主要来源,而肿瘤 97.9% 的剂量是由光源发射的电子造成的。这项研究证明了198金纳米粒子在肿瘤区域实现高剂量浓度的可行性和有效性,同时最大限度地减少了对周围健康组织的照射。研究发现,β发射是肿瘤剂量传递的主要原因,这加强了198金纳米粒子在局部放射治疗中的潜力。我们主张在进一步的研究中使用真实的人体模型,以提高纳米近距离放射治疗剂量测定的可靠性,因为该领域仍然缺乏专门的规程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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