Histologic parameters driving completion thyroidectomy for papillary thyroid carcinoma in a high-volume institution: A retrospective observational study

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2024-10-15 DOI:10.1016/j.amjsurg.2024.116016

Leonardo Rossi , Andrea De Palma , Carlo Enrico Ambrosini , Lorenzo Fregoli , Antonio Matrone , Rossella Elisei , Gabriele Materazzi

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引用次数: 0

Abstract

Background

When the histological examination indicates papillary thyroid carcinoma (PTC), there is no unanimity on the need to proceed with completion thyroidectomy (CT). This study aims to assess the histologic parameters that influenced the decision to perform CT.

Materials and methods

This study included PTC patients who underwent thyroid lobectomy between 2019 and 2022. Group A included patients who underwent thyroid lobectomy without further treatments, whereas Group B included those who underwent CT based on histological findings. Differences in terms of histologic parameters were analyzed.

Results

Group A included 291 patients (68.3 %), whereas Group B 135 patients (31.7 %). Multivariate analysis identified associations between CT and tumor size (p < 0.001), aggressive variant (p = 0.009), and vascular invasion (p < 0.001). ROC curve analysis established a tumor size cut-off of 21 mm for CT. At ROC curve analysis, the cut-off number of aggressive factors required for CT was 2.

Conclusion

A thorough comprehensive assessment encompassing all pathological characteristics might be necessary in case of PTC with aggressive histologic features after thyroid lobectomy.

Abstract Image

查看原文本刊更多论文

在一家高容量医疗机构中，甲状腺乳头状癌组织学参数是完成甲状腺切除术的驱动力：一项回顾性观察研究。

背景：当组织学检查显示为甲状腺乳头状癌（PTC）时，对于是否需要进行完整甲状腺切除术（CT）的意见并不一致。本研究旨在评估影响CT手术决定的组织学参数：本研究纳入了2019年至2022年期间接受甲状腺叶切除术的PTC患者。A组包括未接受进一步治疗而接受甲状腺叶切除术的患者，而B组包括根据组织学结果接受CT检查的患者。分析了组织学参数方面的差异：结果：A组包括291名患者（68.3%），B组包括135名患者（31.7%）。多变量分析确定了 CT 与肿瘤大小之间的关系（P对于甲状腺腺叶切除术后具有侵袭性组织学特征的PTC患者，可能有必要进行包括所有病理特征在内的全面综合评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.