Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults.

IF 7.9 1区 医学 Q1 CLINICAL NEUROLOGY
Jose Bernal, Inga Menze, Renat Yakupov, Oliver Peters, Julian Hellmann-Regen, Silka Dawn Freiesleben, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H Schott, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Sebastian Sodenkamp, Annika Spottke, Anna Esser, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler
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引用次数: 0

Abstract

Background: For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussions about their coupled temporal dynamics. Longitudinal studies supporting this hypothesis nonetheless remain scarce.

Methods: We applied global and regional bivariate latent growth curve modelling to determine the extent to which WMH and cortical thickness were interrelated over a four-year period. For this purpose, we leveraged longitudinal MRI data from 451 cognitively unimpaired participants (DELCODE; median age 69.71 [IQR 65.51, 75.50] years; 52.32% female). Participants underwent MRI sessions annually over a four-year period (1815 sessions in total, with roughly four MRI sessions per participant). We adjusted all models for demographics and cardiovascular risk.

Results: Our findings were three-fold. First, larger WMH volumes were linked to lower cortical thickness (σ = -0.165, SE = 0.047, Z = -3.515, P < 0.001). Second, individuals with higher WMH volumes experienced more rapid cortical thinning (σ = -0.226, SE = 0.093, Z = -2.443, P = 0.007), particularly in temporal, cingulate, and insular regions. Similarly, those with lower initial cortical thickness had faster WMH progression (σ = -0.141, SE = 0.060, Z = -2.336, P = 0.009), with this effect being most pronounced in temporal, cingulate, and insular cortices. Third, faster WMH progression was associated with accelerated cortical thinning (σ = -0.239, SE = 0.139, Z = -1.710, P = 0.044), particularly in frontal, occipital, and insular cortical regions.

Conclusions: Our study suggests that cortical thinning and WMH progression could be mutually reinforcing rather than parallel, unrelated processes, which become entangled before cognitive deficits are detectable.

Trial registration: German Clinical Trials Register (DRKS00007966, 04/05/2015).

有纵向证据表明,在认知能力未受损的老年人中,白质高密度与皮层厚度之间存在相互促进的关系。
背景:三十多年来,皮质神经退行性变和白质高密度(WMH)的同时存在引发了关于两者时间动态耦合的讨论。然而,支持这一假设的纵向研究仍然很少:方法:我们采用全球和区域双变量潜增长曲线模型来确定 WMH 和皮质厚度在四年内的相互关联程度。为此,我们利用了 451 名认知功能未受损的参与者(DELCODE;中位年龄 69.71 [IQR 65.51, 75.50] 岁;52.32% 为女性)的纵向 MRI 数据。在四年的时间里,参与者每年都会接受一次核磁共振成像检查(共进行了 1815 次检查,每位参与者大约接受了四次核磁共振成像检查)。我们对所有模型进行了人口统计学和心血管风险调整:我们的研究结果有三个方面。首先,较大的WMH体积与较低的皮质厚度有关(σ = -0.165,SE = 0.047,Z = -3.515,P 结论:我们的研究表明,皮质厚度越薄,WMH体积越大:我们的研究表明,皮质变薄和WMH进展可能是相互促进的,而不是并行的、不相关的过程,它们在认知障碍被发现之前就已经纠缠在一起了:试验注册:德国临床试验注册中心(DRKS00007966, 04/05/2015)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy 医学-神经病学
CiteScore
13.10
自引率
3.30%
发文量
172
审稿时长
>12 weeks
期刊介绍: Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.
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