Relationship between histological findings of vastus lateralis muscle and function after total hip arthroplasty in patients with hip fracture: a prospective cohort study.

IF 2.5 2区 医学 Q1 ORTHOPEDICS
Suk-Kyoon Song, Ji-Hyun Hwang, Jin-Woo Bae, Hoon-Kyu Oh, Myung-Rae Cho
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Abstract

Background and purpose:  We aimed to examine the histological characteristics of vastus lateralis muscles in patients undergoing total hip arthroplasty (THA) following femoral neck fractures and to explore the correlation between muscle fiber types and postoperative functional recovery.

Methods:  34 patients undergoing THA for femoral neck fractures were included. A biopsy of the vastus lateralis muscle was performed during surgery, followed by immunohistochemical staining. Subsequently, image analysis was conducted to measure the average area of muscle fiber types and the number of type I and II muscle fibers, and the ratio of the area and the number of type II muscle fibers. Functional recovery was assessed 2 weeks post-surgery using the Short Physical Performance Battery (SPPB).

Results: A significant positive correlation was observed between type II muscle fibers and SPPB scores. The ratio of type II muscle fiber area and number strongly correlated with the SPPB scores, indicating a robust static association. The average area of type II fibers showed a strong correlation (r = 0.63, P < 0.001), as did the number of type II fibers (r = 0.53, P = 0.001). Moreover, the ratio of type II muscle fiber area and number significantly correlated with SPPB scores (area: r = 0.77, P < 0.001; number: r = 0.51, P = 0.002), indicating that larger and more numerous type II fibers are associated with better physical performance.

Conclusion: The reduction of type II muscle fibers was strongly correlated with a low SPPB postoperative functional recovery in patients who underwent THA following femoral neck fractures.

髋部骨折患者全髋关节置换术后侧阔肌组织学检查结果与功能之间的关系:一项前瞻性队列研究。
背景和目的:我们旨在研究股骨颈骨折后接受全髋关节置换术(THA)的患者的阔筋膜肌肉组织学特征,并探讨肌肉纤维类型与术后功能恢复之间的相关性。方法:纳入 34 例股骨颈骨折接受 THA 手术的患者,在手术中对股外侧肌进行活检,然后进行免疫组化染色。随后进行图像分析,测量肌纤维类型的平均面积、I型和II型肌纤维的数量,以及II型肌纤维的面积和数量之比。术后两周使用短期体能测试(SPPB)评估功能恢复情况:结果:II型肌纤维与SPPB评分之间存在明显的正相关。II 型肌纤维面积和数量的比率与 SPPB 评分密切相关,表明两者之间存在稳固的静态关联。II 型肌纤维的平均面积(r = 0.63,P < 0.001)和 II 型肌纤维的数量(r = 0.53,P = 0.001)显示出很强的相关性。此外,II型肌纤维面积和数量的比值与SPPB评分显著相关(面积:r = 0.77,P < 0.001;数量:r = 0.51,P = 0.002),这表明更大、更多的II型肌纤维与更好的体能表现有关:结论:在股骨颈骨折后接受 THA 手术的患者中,II 型肌纤维的减少与低 SPPB 术后功能恢复密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Orthopaedica
Acta Orthopaedica 医学-整形外科
CiteScore
6.40
自引率
8.10%
发文量
105
审稿时长
4-8 weeks
期刊介绍: Acta Orthopaedica (previously Acta Orthopaedica Scandinavica) presents original articles of basic research interest, as well as clinical studies in the field of orthopedics and related sub disciplines. Ever since the journal was founded in 1930, by a group of Scandinavian orthopedic surgeons, the journal has been published for an international audience. Acta Orthopaedica is owned by the Nordic Orthopaedic Federation and is the official publication of this federation.
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