PM2.5 is linked to Alzheimer's syndrome and delirium: a mendelian randomization analysis.

IF 1.1 Q4 ONCOLOGY

International journal of clinical and experimental pathology Pub Date : 2024-09-15 eCollection Date: 2024-01-01 DOI:10.62347/FMUC9744

Xiaojin Sun, Xiaofan Yuan, Haoyan Chen, Wenjie Li

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Abstract

Background: Increasing air pollution has drawn our attention to particulate matter (PM2.5), which has been shown to correlate significantly with respiratory and cardiovascular systems. However, whether PM2.5 is causally associated with Alzheimer's syndrome or delirium is unclear.

Methods: We retrieved the genetic summary data of PM2.5 from genome-wide association studies (GWAS). The genetic information for Alzheimer's disease was obtained from the IEU OpenGWAS project, and that for delirium was obtained from FinnGen. We used two-sample Mendelian randomization analysis (MR) to associate PM2.5 with Alzheimer's disease or delirium.

Results: The odds ratio (OR) for Alzheimer's disease was 0.996 with a p-value of 0.443 using the inverse variance weighted algorithm, and the OR associated with the outcome variable of delirium was 0.393 with a p-value of 0.343.

Conclusion: With the exclusion of confounding factors, our findings do not support a genetic association between PM2.5 and Alzheimer's disease or delirium. Further population-based and experimental studies are needed to dissect the complex correlation between PM2.5 and Alzheimer's disease or delirium.

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PM2.5 与阿尔茨海默氏症和谵妄有关：一项亡羊补牢式随机分析。

背景：日益严重的空气污染引起了我们对颗粒物（PM2.5）的关注，它已被证明与呼吸系统和心血管系统密切相关。然而，PM2.5 是否与阿尔茨海默氏症或谵妄有因果关系尚不清楚：我们从全基因组关联研究（GWAS）中检索了 PM2.5 的遗传汇总数据。我们使用双样本孟德尔随机分析（MR）将PM2.5与阿尔茨海默病或谵妄联系起来：使用逆方差加权算法，阿尔茨海默氏症的几率比（OR）为 0.996，P 值为 0.443；与谵妄这一结果变量相关的几率比为 0.393，P 值为 0.343：在排除混杂因素的情况下，我们的研究结果并不支持PM2.5与阿尔茨海默病或谵妄之间存在遗传关联。需要进一步开展基于人群的研究和实验研究，以剖析PM2.5与阿尔茨海默病或谵妄之间复杂的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.