Anti-RBD IgG dynamics following infection or vaccination.

Vaccine Pub Date : 2024-12-02 Epub Date: 2024-10-20 DOI:10.1016/j.vaccine.2024.126464
Amira Harrache, Kahina Saker, Bouchra Mokdad, Laurence Generenaz, Carla Saade, Sylvie Pons, Jean-Baptiste Fassier, Antonin Bal, Mary-Anne Trabaud, Muriel Rabilloud, Amna Abichou-Klich, Sophie Trouillet-Assant
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Abstract

Identifying parameters influencing SARS-CoV-2 antibody dynamics post infection or vaccination is crucial for refining vaccination strategies. In a longitudinal analysis of 1340 samples from 375 healthcare workers, we characterized peak serological response and IgG half-life. Peak antibody titers post 2 vaccine doses were ∼ 20 times higher than natural infection; conversely, infected individuals had extended antibody half-life. Clinical and demographical factors such as BMI, age and smoking shaped peak response without affecting anti-RBD IgG half-life. A third mRNA vaccine dose increased peak antibody titers and prolonged half-life compared to the second dose. These findings underscore the diverse kinetics of SARS-CoV-2 antibody responses, which is influenced by immunization type/number and clinical factors.

感染或接种疫苗后抗 RBD IgG 的动态变化。
确定影响感染或接种后 SARS-CoV-2 抗体动态的参数对于改进疫苗接种策略至关重要。我们对来自 375 名医护人员的 1340 份样本进行了纵向分析,确定了血清反应峰值和 IgG 半衰期。接种 2 剂疫苗后的抗体滴度峰值比自然感染高 20 倍;相反,感染者的抗体半衰期延长。临床和人口统计学因素(如体重指数、年龄和吸烟)会影响峰值反应,但不会影响抗 RBD IgG 的半衰期。与第二剂相比,第三剂 mRNA 疫苗可提高抗体滴度峰值并延长半衰期。这些研究结果表明,SARS-CoV-2 抗体反应的动力学变化受免疫类型/次数和临床因素的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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