Transcriptomics analyses combined with intestinal microorganism survey suggest Resveratrol (RSV) anti-aging and anti-oxidant effects in silkworm (Bombyx mori)

IF 2.2 2区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Comparative Biochemistry and Physiology D-Genomics & Proteomics Pub Date : 2024-10-15 DOI:10.1016/j.cbd.2024.101344

Liang Chen , Jiaxin Zhang , Lei Ding , Tongyu Gu , Vivian Andoh , Aiqin Ma , Chun Yao

{"title":"Transcriptomics analyses combined with intestinal microorganism survey suggest Resveratrol (RSV) anti-aging and anti-oxidant effects in silkworm (Bombyx mori)","authors":"Liang Chen , Jiaxin Zhang , Lei Ding , Tongyu Gu , Vivian Andoh , Aiqin Ma , Chun Yao","doi":"10.1016/j.cbd.2024.101344","DOIUrl":null,"url":null,"abstract":"<div><div>The growing elderly population presents a significant concern, with the prolongation of life expectancy, aging diseases are becoming increasingly common. Resveratrol (RSV) has emerged as a promising compound for disease prevention. However, the effect of RSV on lifespan extension in different organisms, particularly the model organism silkworm, remains inconsistent. We conducted aging experiments using silkworm (<em>B. mori</em>) and employed transcriptomics to investigate the therapeutic effects of RSV on lifespan extension and healthy lifespan in silkworms. RSV increased the survival rate by 8.57 %–12.12 % and enhanced the antioxidant capacity of silkworms. Transcriptomic analysis demonstrated that genes in signaling pathways such as <em>AMPK</em> and <em>FoxO</em> were significantly upregulated. 16SrRNA sequencing of gut contents showed an increase in beneficial bacterial strains under the action of RSV. This study aims to enhance our understanding of lifespan regulation mechanisms using the silkworm model and provide new targets for anti-aging antioxidants research to delay the onset of age-related diseases.</div></div>","PeriodicalId":55235,"journal":{"name":"Comparative Biochemistry and Physiology D-Genomics & Proteomics","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative Biochemistry and Physiology D-Genomics & Proteomics","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1744117X24001576","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The growing elderly population presents a significant concern, with the prolongation of life expectancy, aging diseases are becoming increasingly common. Resveratrol (RSV) has emerged as a promising compound for disease prevention. However, the effect of RSV on lifespan extension in different organisms, particularly the model organism silkworm, remains inconsistent. We conducted aging experiments using silkworm (B. mori) and employed transcriptomics to investigate the therapeutic effects of RSV on lifespan extension and healthy lifespan in silkworms. RSV increased the survival rate by 8.57 %–12.12 % and enhanced the antioxidant capacity of silkworms. Transcriptomic analysis demonstrated that genes in signaling pathways such as AMPK and FoxO were significantly upregulated. 16SrRNA sequencing of gut contents showed an increase in beneficial bacterial strains under the action of RSV. This study aims to enhance our understanding of lifespan regulation mechanisms using the silkworm model and provide new targets for anti-aging antioxidants research to delay the onset of age-related diseases.

Abstract Image

查看原文本刊更多论文

结合肠道微生物调查进行的转录组学分析表明，白藜芦醇（RSV）对家蚕（Bombyx mori）具有抗衰老和抗氧化作用。

随着预期寿命的延长，老龄化疾病越来越常见，老年人口的不断增长引起了人们的极大关注。白藜芦醇（RSV）已成为一种有希望预防疾病的化合物。然而，RSV 对不同生物（尤其是模式生物家蚕）寿命延长的影响仍不一致。我们利用家蚕（B. mori）进行了衰老实验，并采用转录组学研究了RSV对家蚕寿命延长和健康寿命的治疗作用。RSV可使蚕的存活率提高8.57%-12.12%，并增强蚕的抗氧化能力。转录组分析表明，AMPK 和 FoxO 等信号通路中的基因明显上调。肠道内容物的 16SrRNA 测序显示，在 RSV 的作用下，有益细菌菌株有所增加。这项研究旨在利用家蚕模型加深我们对寿命调控机制的理解，并为抗衰老抗氧化剂研究提供新的靶点，以延缓老年相关疾病的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Comparative Biochemistry and Physiology D-Genomics & Proteomics 生物-生化与分子生物学

CiteScore

5.10

自引率

3.30%

发文量

审稿时长

33 days

期刊介绍： Comparative Biochemistry & Physiology (CBP) publishes papers in comparative, environmental and evolutionary physiology. Part D: Genomics and Proteomics (CBPD), focuses on “omics” approaches to physiology, including comparative and functional genomics, metagenomics, transcriptomics, proteomics, metabolomics, and lipidomics. Most studies employ “omics” and/or system biology to test specific hypotheses about molecular and biochemical mechanisms underlying physiological responses to the environment. We encourage papers that address fundamental questions in comparative physiology and biochemistry rather than studies with a focus that is purely technical, methodological or descriptive in nature.