First In-Vivo demonstration of 1000fps High Speed Coronary Angiography (HSCA) in a swine animal model.

S V Setlur Nagesh, E Vanderbilt, C Koenigsknecht, D Pionessa, V K Chivukula, C N Ionita, David M Zlotnick, D R Bednarek, S Rudin
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Abstract

High-speed-angiography (HSA) 1000 fps imaging was successfully used previously to visualize contrast media/blood flow in neurovascular anatomies. In this work we explore its usage in cardiovascular anatomies in a swine animal model. A 5 French catheter was guided into the right coronary artery of a swine, followed by the injection of iodine contrast through a computer-controlled injector at a controlled rate of 40 (ml/min). The injection process was captured using high-speed angiography at a rate of 1000 fps. The noise in the images was reduced using a custom built machine-learning model consisting of Long Short-term memory networks. From the noise reduced images, velocity profiles of contrast/blood flow through the artery was calculated using Horn-Schunck optical flow (OF) method. From the high-speed coronary angiography (HSCA) images, the bolus of contrast could be visually tracked with ease as it traversed from the catheter tip through the artery. The imaging technique's high temporal resolution effectively minimized motion artifacts resulting from the heart's activity. The OF results of the contrast injection show velocities in the artery ranging from 20 - 40 cm/s. The results demonstrate the potential of 1000 fps HSCA in cardiovascular imaging. The combined high spatial and temporal resolution offered by this technique allows for the derivation of velocity profiles throughout the artery's structure, including regions distal and proximal to stenoses. This information can potentially be used to determine the need for stenoses treatment. Further investigations are warranted to expand our understanding of the applications of HSCA in cardiovascular research and clinical practice.

首次在猪动物模型中进行 1000fps 高速冠状动脉造影 (HSCA) 的体内演示。
高速血管造影(HSA)1000 fps 成像曾成功用于观察神经血管解剖中的造影剂/血流。在这项工作中,我们在猪动物模型中探索了其在心血管解剖中的应用。将一根 5 French 导管导入猪的右冠状动脉,然后通过计算机控制的注射器以每分钟 40 毫升的速度注射碘造影剂。注射过程使用高速血管成像技术以 1000 fps 的速度拍摄。使用由长短期记忆网络组成的定制机器学习模型降低了图像中的噪音。根据降噪后的图像,采用霍恩-舒伦克光流(OF)方法计算出对比剂/血液流经动脉的速度曲线。从高速冠状动脉造影(HSCA)图像中,可以直观地追踪造影剂从导管尖端穿过动脉的过程。成像技术的高时间分辨率有效地减少了心脏活动造成的运动伪影。造影剂注射的 OF 结果显示,动脉中的速度为 20-40 厘米/秒。这些结果证明了 1000 fps HSCA 在心血管成像方面的潜力。该技术结合了高空间分辨率和高时间分辨率,可以得出整个动脉结构的速度曲线,包括狭窄远端和近端区域。这些信息可用于确定是否需要对狭窄部位进行治疗。我们有必要开展进一步的研究,以扩大我们对 HSCA 在心血管研究和临床实践中的应用的了解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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