Genetic markers and predictive model for individual differences in countermovement jump enhancement after resistance training.

IF 4.2 2区 医学 Q1 SPORT SCIENCES
Biology of Sport Pub Date : 2024-10-01 Epub Date: 2024-04-09 DOI:10.5114/biolsport.2024.136088
Tao Mei, Xiaoxia Li, Yanchun Li, Xiaolin Yang, Liang Li, Zihong He
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引用次数: 0

Abstract

This study aims to utilize Genome-Wide Association Analysis (GWAS) to identify genetic markers associated with enhanced power resulting from resistance training. Additionally, we analyze the potential biological effects of these markers and establish a predictive model for training outcomes. 193 Han Chinese adults (age: 20 ± 1 years) underwent resistance training involving squats and bench presses at 70% 1RM, twice weekly, 5 sets × 10 repetitions, for 12 weeks. Whole-genome genotyping was conducted, and participants' countermovement jump (CMJ) height, lower limb muscle strength, and body muscle mass were assessed. CMJ height change was used to assess changes in power and subjected to Genome-Wide Association Analysis (GWAS) against genotypes. Employing Polygenic Score (PGS) calculations and stepwise linear regression, a predictive model for training effects was constructed. The results revealed a significant increase in CMJ height among participants following the resistance training intervention (Δ% = 16.53%, p < 0.01), with individual differences ranging from -35.90% to 125.71%. 38 lead SNPs, including PCTP rs9907859 (p < 1 × 10-8), showed significant associations with the percentage change in CMJ height after training (p < 1 × 10-5). The explanatory power of the predictive model for training outcomes, established using PGS and phenotypic indicators, was 62.6%, comprising 13.0% from PGS and 49.6% from phenotypic indicators. SNPs associated with power resistance training were found to participate in the biological processes of musculoskeletal movement and the Striated muscle contraction pathway. These findings indicate that individual differences in the training effect of CMJ exist after resistance training, partially explained by genetic markers and phenotypic indicators (62.6%).

阻力训练后反向跳跃增强个体差异的遗传标记和预测模型。
本研究旨在利用全基因组关联分析(GWAS)确定与阻力训练增强力量相关的遗传标记。此外,我们还分析了这些标记的潜在生物学效应,并建立了一个训练结果预测模型。193 名汉族成年人(年龄:20 ± 1 岁)接受了阻力训练,包括深蹲和卧推,训练强度为 70% 1RM,每周两次,每次 5 组 × 10 次,为期 12 周。研究人员进行了全基因组基因分型,并评估了参与者的反运动跳跃(CMJ)高度、下肢肌肉力量和身体肌肉质量。CMJ高度变化用于评估力量变化,并针对基因型进行全基因组关联分析(GWAS)。通过多基因评分(PGS)计算和逐步线性回归,构建了训练效果预测模型。结果显示,在阻力训练干预后,参与者的CMJ高度明显增加(Δ% = 16.53%,P < 0.01),个体差异在-35.90%到125.71%之间。包括 PCTP rs9907859(p < 1 × 10-8)在内的 38 个先导 SNP 与训练后 CMJ 高度的百分比变化有显著关联(p < 1 × 10-5)。利用 PGS 和表型指标建立的训练结果预测模型的解释力为 62.6%,其中 13.0% 来自 PGS,49.6% 来自表型指标。研究发现,与力量阻力训练相关的 SNPs 参与了肌肉骨骼运动和横纹肌收缩途径的生物过程。这些研究结果表明,阻力训练后CMJ的训练效果存在个体差异,遗传标记和表型指标(62.6%)可以部分解释这种差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biology of Sport
Biology of Sport 生物-运动科学
CiteScore
8.20
自引率
12.50%
发文量
113
审稿时长
>12 weeks
期刊介绍: Biology of Sport is the official journal of the Institute of Sport in Warsaw, Poland, published since 1984. Biology of Sport is an international scientific peer-reviewed journal, published quarterly in both paper and electronic format. The journal publishes articles concerning basic and applied sciences in sport: sports and exercise physiology, sports immunology and medicine, sports genetics, training and testing, pharmacology, as well as in other biological aspects related to sport. Priority is given to inter-disciplinary papers.
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