Improved functional oral intake and exercise training attenuate decline in aerobic capacity following chemoradiotherapy in patients with esophageal cancer.

IF 2.5 4区 医学 Q1 REHABILITATION
Shu-Chun Huang, Lan-Yan Yang, Yin-Kai Chao, Wei-Yang Chang, Ya-Tzu Tsao, Chuan-Yi Chou, Ching-Chung Hsiao, Chien-Hung Chiu
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Abstract

Purpose: To investigate the impact of chemoradiotherapy on the physical fitness of patients with oesophageal cancer, and the clinical factors influencing it.

Method: A total of 67 participants successfully completed the study, with 18 of them engaging in supervised, in-hospital aerobic training at moderate intensity for a minimum of 20 sessions. Cardiopulmonary exercise testing, hand grip strength, body composition assessed via bioelectrical impedance analysis, patient-generated subjective global assessment, albumin, and the Functional Oral Intake Scale (FOIS) were evaluated before chemoradiotherapy and 6-8 weeks after its completion.

Result: Among the participants, cardiopulmonary fitness, hand grip strength, and phase angle of BC-BIA declined during chemoradiotherapy. Before and after chemoradiotherapy, V̇O2peak was 19.6 ± 4.4 and 17.4 ± 3.9 mL/min/kg respectively. The improvement in FOIS during chemoradiotherapy showed a positive correlation with changes in aerobic capacity. Additionally, exercise training was associated with attenuating the decline in aerobic capacity.

Conclusion: Physical fitness deteriorated in patients with oesophageal cancer following chemoradiotherapy. Improvement in dysphagia helps maintain aerobic capacity. Additionally, exercise training has the potential to mitigate the decline. This discovery can serve as a reference for enhancing holistic care for patients with oesophageal cancer.

改善功能性口腔摄入和运动训练可减轻食道癌患者化放疗后有氧运动能力的下降。
目的:探讨化放疗对食道癌患者体能的影响以及影响因素:共有 67 人成功完成了研究,其中 18 人在监督下进行了至少 20 次中等强度的院内有氧训练。在化疗前和化疗结束后 6-8 周,对心肺运动测试、手部握力、通过生物电阻抗分析评估的身体成分、患者主观总体评估、白蛋白和功能性口腔摄入量表(FOIS)进行了评估:结果:化疗期间,参与者的心肺功能、手握力和BC-BIA相位角均有所下降。化疗前后,V.̇O2peak分别为19.6±4.4和17.4±3.9 mL/min/kg。化放疗期间FOIS的改善与有氧能力的变化呈正相关。此外,运动训练与减轻有氧能力的下降有关:结论:化疗放疗后,食道癌患者的体能有所下降。吞咽困难的改善有助于维持有氧运动能力。此外,运动训练也有可能缓解体能下降。这一发现可为加强食道癌患者的整体护理提供参考。
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来源期刊
CiteScore
5.60
自引率
5.70%
发文量
102
审稿时长
4-8 weeks
期刊介绍: Journal of Rehabilitation Medicine is an international peer-review journal published in English, with at least 10 issues published per year. Original articles, reviews, case reports, short communications, special reports and letters to the editor are published, as also are editorials and book reviews. The journal strives to provide its readers with a variety of topics, including: functional assessment and intervention studies, clinical studies in various patient groups, methodology in physical and rehabilitation medicine, epidemiological studies on disabling conditions and reports on vocational and sociomedical aspects of rehabilitation.
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