Multiple myeloma segmentation net (MMNet): an encoder-decoder-based deep multiscale feature fusion model for multiple myeloma segmentation in magnetic resonance imaging.

Abstract

Background: Patients with multiple myeloma (MM), a malignant disease involving bone marrow plasma cells, shows significant susceptibility to bone degradation, impairing normal hematopoietic function. The accurate and effective segmentation of MM lesion areas is crucial for the early detection and diagnosis of myeloma. However, the presence of complex shape variations, boundary ambiguities, and multiscale lesion areas, ranging from punctate lesions to extensive bone damage, presents a formidable challenge in achieving precise segmentation. This study thus aimed to develop a more accurate and robust segmentation method for MM lesions by extracting rich multiscale features.

Methods: In this paper, we propose a novel, multiscale feature fusion encoding-decoding model architecture specifically designed for MM segmentation. In the encoding stage, our proposed multiscale feature extraction module, dilated dense connected net (DCNet), is employed to systematically extract multiscale features, thereby augmenting the model's sensing field. In the decoding stage, we propose the CBAM-atrous spatial pyramid pooling (CASPP) module to enhance the extraction of multiscale features, enabling the model to dynamically prioritize both channel and spatial information. Subsequently, these features are concatenated with the final output feature map to optimize segmentation outcomes. At the feature fusion bottleneck layer, we incorporate the dynamic feature fusion (DyCat) module into the skip connection to dynamically adjust feature extraction parameters and fusion processes.

Results: We assessed the efficacy of our approach using a proprietary dataset of MM, yielding notable advancements. Our dataset comprised 753 magnetic resonance imaging (MRI) two-dimensional (2D) slice images of the spinal regions from 45 patients with MM, along with their corresponding ground truth labels. These images were primarily obtained from three sequences: T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and short tau inversion recovery (STIR). Using image augmentation techniques, we expanded the dataset to 3,000 images, which were employed for both model training and prediction. Among these, 2,400 images were allocated for training purposes, while 600 images were reserved for validation and testing. Our method showed increase in the intersection over union (IoU) and Dice coefficients by 7.9 and 6.7 percentage points, respectively, as compared to the baseline model. Furthermore, we performed comparisons with alternative image segmentation methodologies, which confirmed the sophistication and efficacy of our proposed model.

Conclusions: Our proposed multiple myeloma segmentation net (MMNet), can effectively extract multiscale features from images and enhance the correlation between channel and spatial information. Furthermore, a systematic evaluation of the proposed network architecture was conducted on a self-constructed, limited dataset. This endeavor holds promise for offering valuable insights into the development of algorithms for future clinical applications.