Myriad of factors involved in blood pressure control. Salt intake connects them all.

IF 2 4区 医学 Q3 PHYSIOLOGY
Journal of Physiology and Pharmacology Pub Date : 2024-08-01 Epub Date: 2024-10-10 DOI:10.26402/jpp.2024.4.01
M Kuczeriszka, L Dobrowolski
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引用次数: 0

Abstract

Long-lasting elevated blood pressure (BP), i.e. hypertension, is a major contributor to morbidity and mortality worldwide. As a multifactorial and systemic disease that involves multiple systems, hypertension remains a challenging disease to study. Models of hypertension are a basic source of knowledge to drive and support the discovery of the specific genetic, cellular, and molecular mechanisms underlying essential hypertension, as well as to discover and introduce new possible treatments to lower BP. Animal models of hypertension deliver a huge amount of information but it is important to choose the proper one for our scientific hypothesis. In this review, we discuss the physiological, and biochemical background of rodent models of hypertension through a systems approach and a myriad of mechanisms and pathways involved in blood pressure control. We also pay attention to how target organs and systems including the kidneys, vasculature, the sympathetic nervous system (SNS), and immunological system, interfere with each other, and their activity is differentially controlled by sodium delivery, which still remains a pivotal troublemaker.

血压控制涉及众多因素。盐的摄入将它们全部联系在一起。
长期血压(BP)升高,即高血压,是导致全球发病率和死亡率的一个主要因素。作为一种涉及多个系统的多因素系统性疾病,高血压仍然是一种极具挑战性的疾病。高血压模型是基本的知识来源,可推动和支持发现本质高血压的特定遗传、细胞和分子机制,以及发现和引入降低血压的新疗法。高血压动物模型提供了大量信息,但重要的是要为我们的科学假设选择合适的动物模型。在这篇综述中,我们将通过系统方法讨论高血压啮齿动物模型的生理和生化背景,以及参与血压控制的无数机制和途径。我们还关注包括肾脏、血管、交感神经系统(SNS)和免疫系统在内的目标器官和系统如何相互干扰,以及它们的活动如何受到钠输送的不同控制,而钠输送仍然是一个关键的麻烦制造者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
22.70%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Journal of Physiology and Pharmacology publishes papers which fall within the range of basic and applied physiology, pathophysiology and pharmacology. The papers should illustrate new physiological or pharmacological mechanisms at the level of the cell membrane, single cells, tissues or organs. Clinical studies, that are of fundamental importance and have a direct bearing on the pathophysiology will also be considered. Letters related to articles published in The Journal with topics of general professional interest are welcome.
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