Determining the expression of vitamin D receptor, regulator of iron metabolism hepcidin and cathelicidin antimicrobial peptide genes for development of future diagnostic and therapeutic options in patients with inflammatory bowel disease.

IF 2 4区 医学 Q3 PHYSIOLOGY
Journal of Physiology and Pharmacology Pub Date : 2024-08-01 Epub Date: 2024-10-10 DOI:10.26402/jpp.2024.4.06
N Fabisiak, A Tarasiuk-Zawadzka, A Fabisiak, M Wlodarczyk, J Fichna
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引用次数: 0

Abstract

Patients with inflammatory bowel diseases (IBD) frequently experience malnutrition and develop nutrients deficiencies such as vitamin D or iron. Collectively, 39 patients were recruited to the study - 32 with IBD and 7 patients constituting the control group (CG). Quantitative real-time polymerase chain reaction was used to assess the expression of vitamin D receptor (VDR), hepcidin (HAMP) and cathelicidin antimicrobial peptide (CAMP) in colon mucosa. The mean expression of VDR and CAMP was higher in patients with ulcerative colitis than other groups (VDR vs. CG, p<0.05). However, the mean HAMP expression reached higher values in CG than in groups with IBD. Further research to understand the relationship between the VDR, HAMP and CAMP may constitute the way for development of future diagnostic and therapeutic options in patients with IBD.

确定维生素 D 受体、铁代谢调节剂肝磷脂素和 cathelicidin 抗菌肽基因的表达情况,以便为炎症性肠病患者开发未来的诊断和治疗方案。
炎症性肠病(IBD)患者经常会出现营养不良和维生素 D 或铁等营养素缺乏症。本研究共招募了 39 名患者--32 名 IBD 患者和 7 名对照组(CG)患者。研究采用定量实时聚合酶链反应评估结肠粘膜中维生素 D 受体(VDR)、肝素(HAMP)和柔毛素抗菌肽(CAMP)的表达。溃疡性结肠炎患者 VDR 和 CAMP 的平均表达量高于其他组别(VDR 与 CG 相比,p
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来源期刊
CiteScore
4.00
自引率
22.70%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Journal of Physiology and Pharmacology publishes papers which fall within the range of basic and applied physiology, pathophysiology and pharmacology. The papers should illustrate new physiological or pharmacological mechanisms at the level of the cell membrane, single cells, tissues or organs. Clinical studies, that are of fundamental importance and have a direct bearing on the pathophysiology will also be considered. Letters related to articles published in The Journal with topics of general professional interest are welcome.
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