Metabolic Pathways Associated With Obesity and Hypertension in Black Caregivers of Persons Living With Dementia.

IF 2.2 4区 医学 Q1 NURSING
Nursing Research Pub Date : 2025-01-01 Epub Date: 2024-10-10 DOI:10.1097/NNR.0000000000000783
Glenna S Brewster, Madelyn C Houser, Irene Yang, Jordan Pelkmans, Melinda Higgins, Cristy Tower-Gilchrist, Jessica Wells, Arshed A Quyyumi, Dean Jones, Sandra B Dunbar, Nicole Carlson
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引用次数: 0

Abstract

Background: In the United States, Black adults have the highest prevalence of obesity and hypertension, increasing their risk of morbidity and mortality. Caregivers of persons with dementia are also at increased risk of morbidity and mortality due to the demands of providing care. Thus, Black caregivers-who are the second largest group of caregivers of persons with dementia in the United States-have the highest risks for poor health outcomes among all caregivers. However, the physiological changes associated with multiple chronic conditions in Black caregivers are poorly understood.

Objectives: In this study, metabolomics were compared to the metabolic profiles of Black caregivers with obesity, with or without hypertension. Our goal was to identify metabolites and metabolic pathways that could be targeted to reduce obesity and hypertension rates in this group.

Methods: High-resolution, untargeted metabolomic assays were performed on plasma samples from 26 self-identified Black caregivers with obesity, 18 of whom had hypertension. Logistic regression and pathway analyses were employed to identify metabolites and metabolic pathways differentiating caregivers with obesity only and caregivers with both obesity and hypertension.

Results: Key metabolic pathways discriminating caregivers with obesity only and caregivers with obesity and hypertension were butanoate and glutamate metabolism, fatty acid activation/biosynthesis, and the carnitine shuttle pathway. Metabolites related to glutamate metabolism in the butanoate metabolism pathway were more abundant in caregivers with hypertension, while metabolites identified as butyric acid/butanoate and R-(3)-hydroxybutanoate were less abundant. Caregivers with hypertension also had lower levels of several unsaturated fatty acids.

Discussion: In Black caregivers with obesity, multiple metabolic features and pathways differentiated among caregivers with and without hypertension. If confirmed in future studies, these findings would support ongoing clinical monitoring and culturally tailored interventions focused on nutrition (particularly polyunsaturated fats and animal protein), exercise, and stress management to reduce the risk of hypertension in Black caregivers with obesity.

与痴呆症患者黑人护理者肥胖和高血压有关的代谢途径。
背景:在美国,黑人成年人的肥胖症和高血压发病率最高,这增加了他们发病和死亡的风险。痴呆症患者的护理者由于需要提供护理,发病和死亡的风险也会增加。因此,黑人护理者是美国痴呆症患者护理者的第二大群体,在所有护理者中健康状况不佳的风险最高。然而,人们对黑人护理者与多种慢性疾病相关的生理变化知之甚少:在这项研究中,我们将代谢组学与患有或不患有高血压的肥胖症黑人护理人员的代谢特征进行了比较。我们的目标是找出可用于降低该群体肥胖症和高血压发病率的代谢物和代谢途径。方法:对 26 名自我认定患有肥胖症的黑人护理人员(其中 18 人患有高血压)的血浆样本进行了高分辨率、非靶向代谢组学检测。通过逻辑回归和途径分析,确定了区分肥胖症护理人员和肥胖症与高血压护理人员的代谢物和代谢途径:结果:区分肥胖症护理人员与肥胖症和高血压护理人员的主要代谢途径是丁酸和谷氨酸代谢、脂肪酸活化/生物合成以及肉碱穿梭途径。在丁酸代谢途径中,与谷氨酸代谢有关的代谢物在患有高血压的护理人员中含量较高,而被鉴定为丁酸/丁酸和R-(3)-羟基丁酸的代谢物含量较低。患有高血压的护理人员体内几种不饱和脂肪酸的含量也较低:在患有肥胖症的黑人护理人员中,患有高血压和未患有高血压的护理人员之间存在多种代谢特征和途径的差异。如果在未来的研究中得到证实,这些发现将支持持续的临床监测和文化定制干预,重点关注营养(尤其是多不饱和脂肪和动物蛋白)、运动和压力管理,以降低肥胖症黑人护理者的高血压风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nursing Research
Nursing Research 医学-护理
CiteScore
3.60
自引率
4.00%
发文量
102
审稿时长
6-12 weeks
期刊介绍: Nursing Research is a peer-reviewed journal celebrating over 60 years as the most sought-after nursing resource; it offers more depth, more detail, and more of what today''s nurses demand. Nursing Research covers key issues, including health promotion, human responses to illness, acute care nursing research, symptom management, cost-effectiveness, vulnerable populations, health services, and community-based nursing studies. Each issue highlights the latest research techniques, quantitative and qualitative studies, and new state-of-the-art methodological strategies, including information not yet found in textbooks. Expert commentaries and briefs are also included. In addition to 6 issues per year, Nursing Research from time to time publishes supplemental content not found anywhere else.
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