Ring-Enhancement on CEUS: Is it Useful in the Differential Diagnosis of Solid Thyroid Nodules?

IF 2.5 4区 医学 Q1 ACOUSTICS
Tingting Li, Lijuan Mao, Xi Wang, Cuixian Li, Caihong Dong, Wenqing Wu, Hantao Wang, Qing Lu
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Abstract

To investigate the efficiency of contrast-enhanced ultrasound (CEUS) features, particularly ring-enhancement patterns, in the differential diagnosis of thyroid nodules. 302 nodules with CEUS ring-enhancement were retrospectively enrolled, including 135 benign and 167 malignant ones. The ring-enhancement patterns were classified into regular and irregular hyper- or hypo-ring enhancement. Comparative analyses of ultrasound (US) and CEUS features between benign and malignant nodules were performed. The diagnostic performances of the ring-enhancement patterns and Chinese Thyroid Imaging Reporting and Data System (C-TIRADS) were compared in nodules with different sizes. Irregular hypo-ring enhancement was much more common in malignancies than that in benign ones, and it was an independent predictor for thyroid malignant nodules. With irregular hypo-ring enhancement as the diagnostic criteria for malignant nodules, the specificity was higher than that of C-TIRADS (85.2% vs. 75.6%, p = .037) while the AUC was comparable (0.845 vs. 0.803, p = .136) in all nodules. When the nodule size was taken into account, the specificity and AUC were both significantly higher than those of C-TIRADS (92.8% vs. 81.1%, p = .021; 0.907 vs. 0.823, p = .026) in nodules ≥10 mm, which can decrease the unnecessary FNA rate. Irregular hypo-ring enhancement was a valuable CEUS feature for the differential diagnosis of thyroid nodules, especially in nodules ≥10 mm.

CEUS上的环增强:它在甲状腺实性结节的鉴别诊断中有用吗?
研究对比增强超声(CEUS)特征,尤其是环状增强模式在甲状腺结节鉴别诊断中的有效性。回顾性收集了302个有CEUS环形增强的结节,其中包括135个良性结节和167个恶性结节。环状增强模式分为规则环状增强和不规则环状增强。对良性和恶性结节的超声(US)和 CEUS 特征进行了比较分析。比较了环状增强模式和中国甲状腺影像报告和数据系统(C-TIRADS)对不同大小结节的诊断性能。不规则低环增强在恶性结节中比在良性结节中更常见,是甲状腺恶性结节的独立预测指标。将不规则低环强化作为恶性结节的诊断标准,其特异性高于 C-TIRADS (85.2% 对 75.6%,p = 0.037),而在所有结节中的 AUC 值相当(0.845 对 0.803,p = 0.136)。如果考虑到结节的大小,对于≥10 毫米的结节,其特异性和 AUC 均明显高于 C-TIRADS(92.8% vs. 81.1%,p = .021;0.907 vs. 0.823,p = .026),这可以降低不必要的 FNA 率。不规则低环强化是鉴别诊断甲状腺结节的一个有价值的 CEUS 特征,尤其是在≥10 毫米的结节中。
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来源期刊
Ultrasonic Imaging
Ultrasonic Imaging 医学-工程:生物医学
CiteScore
5.10
自引率
8.70%
发文量
15
审稿时长
>12 weeks
期刊介绍: Ultrasonic Imaging provides rapid publication for original and exceptional papers concerned with the development and application of ultrasonic-imaging technology. Ultrasonic Imaging publishes articles in the following areas: theoretical and experimental aspects of advanced methods and instrumentation for imaging
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