[Severe intoxication after yew (Taxus) ingestion-case report and literature review].

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medizinische Klinik-Intensivmedizin Und Notfallmedizin Pub Date : 2024-10-21 DOI:10.1007/s00063-024-01187-z

J L Lohmeyer, C Enneking, P Mammen, T Horlacher, M Roiss, G N Schmidt, M W Bergmann, T Spangenberg

{"title":"[Severe intoxication after yew (Taxus) ingestion-case report and literature review].","authors":"J L Lohmeyer, C Enneking, P Mammen, T Horlacher, M Roiss, G N Schmidt, M W Bergmann, T Spangenberg","doi":"10.1007/s00063-024-01187-z","DOIUrl":null,"url":null,"abstract":"Background: Severe yew (Taxus) intoxication is a rare condition that can lead to life-threatening cardiac arrhythmia. The survival of patients requires highly specialized emergency and intensive care treatment.Objectives: Systematic overview of the clinical picture and important treatment options.Methods: Case report of severe yew intoxication with subsequent literature review of comparable case reports. Analysis of 33 case reports with a total of 37 critically intoxicated patients from the years 2000-2024 from Europe and North America.Results: Severe yew intoxications were almost exclusively the result of suicidal intent. Patients average age was 33 (± 14.5) years. The use of antiarrhythmic drugs and electrical stimulation of the heart often proved to be ineffective or deteriorating in its effect over time. The use of lipid emulsion and/or digoxin-specific Fab fragments has little evidence. The average duration of a clinically relevant arrhythmogenic effect was 22±11.7 h.Conclusions: The management of yew intoxication is primarily limited to symptomatic treatment. The availability of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in a \"bridge-to-recovery\" concept appears to be of utmost importance.","PeriodicalId":49019,"journal":{"name":"Medizinische Klinik-Intensivmedizin Und Notfallmedizin","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medizinische Klinik-Intensivmedizin Und Notfallmedizin","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00063-024-01187-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Severe yew (Taxus) intoxication is a rare condition that can lead to life-threatening cardiac arrhythmia. The survival of patients requires highly specialized emergency and intensive care treatment.

Objectives: Systematic overview of the clinical picture and important treatment options.

Methods: Case report of severe yew intoxication with subsequent literature review of comparable case reports. Analysis of 33 case reports with a total of 37 critically intoxicated patients from the years 2000-2024 from Europe and North America.

Results: Severe yew intoxications were almost exclusively the result of suicidal intent. Patients average age was 33 (± 14.5) years. The use of antiarrhythmic drugs and electrical stimulation of the heart often proved to be ineffective or deteriorating in its effect over time. The use of lipid emulsion and/or digoxin-specific Fab fragments has little evidence. The average duration of a clinically relevant arrhythmogenic effect was 22±11.7 h.

Conclusions: The management of yew intoxication is primarily limited to symptomatic treatment. The availability of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in a "bridge-to-recovery" concept appears to be of utmost importance.

查看原文本刊更多论文

[摄入紫杉后严重中毒--病例报告和文献综述]。

背景：严重紫杉中毒是一种罕见病，可导致危及生命的心律失常。患者的存活需要高度专业化的急诊和重症监护治疗：系统概述临床表现和重要的治疗方案：方法：严重紫杉中毒的病例报告，随后对类似病例报告进行文献综述。分析 2000 年至 2024 年欧洲和北美的 33 份病例报告，共计 37 名重度中毒患者：结果：严重紫杉中毒几乎全部是自杀意图所致。患者的平均年龄为 33（± 14.5）岁。事实证明，使用抗心律失常药物和心脏电刺激往往无效，或者随着时间的推移效果越来越差。使用脂质乳剂和/或地高辛特异性 Fab 片段的证据很少。临床相关的致心律失常作用的平均持续时间为 22±11.7 小时：结论：对紫杉中毒的治疗主要限于对症治疗。结论：对紫杉中毒的治疗主要局限于对症治疗，在 "康复之桥 "概念中，静脉体外膜肺氧合（VA-ECMO）的可用性似乎至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medizinische Klinik-Intensivmedizin Und Notfallmedizin MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Medizinische Klinik – Intensivmedizin und Notfallmedizin is an internationally respected interdisciplinary journal. It is intended for physicians, nurses, respiratory and physical therapists active in intensive care and accident/emergency units, but also for internists, anesthesiologists, surgeons, neurologists, and pediatricians with special interest in intensive care medicine. Comprehensive reviews describe the most recent advances in the field of internal medicine with special focus on intensive care problems. Freely submitted original articles present important studies in this discipline and promote scientific exchange, while articles in the category Photo essay feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. In the rubric journal club well-respected experts comment on outstanding international publications. Review articles under the rubric "Continuing Medical Education" present verified results of scientific research and their integration into daily practice. The rubrics "Nursing practice" and "Physical therapy" round out the information.