Decreased Nuclear Immunoexpression of ING3 is a Frequent Event in Lip Carcinogenesis.

IF 3.2 Q2 PATHOLOGY
Joyce Magalhães de Barros, Hannah Gil de Farias Morais, Carla Samily de Oliveira Costa, Larissa Santos Amaral Rolim, Maria Luiza Diniz de Sousa Lopes, Lélia Maria Guedes Queiroz, Lélia Batista de Souza, Leão Pereira Pinto
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Abstract

Purpose: Evaluate the immunohistochemical expression of the ING3 in actinic cheilitis and squamous cell carcinoma of the lower lip.

Methods: Forty-five specimens of actinic cheilitis and 48 specimens of squamous cell carcinoma of the lower lip were submitted to immunohistochemical detection of ING3. The protein expression in different cellular sublocations was compared between the two groups, and associations with the clinicopathological variables were analyzed. A significance level of 5% was adopted for all tests.

Results: Deaths were significantly more frequent in tumors with a high histopathological risk score (p < 0.05). In actinic cheilitis, significant differences were found in the nucleus-cytoplasmic expression of ING3 and expression restricted to the cytoplasm with binary histopathological grading (p < 0.05). In squamous cell carcinoma of the lower lip, there was no statistically significant difference when comparing ING3 expressions with clinical and morphological parameters (p > 0.05). Nucleo-cytoplasmic ING3 expression was significantly lower in squamous cell carcinoma of the lower lip when compared to actinic cheilitis (p < 0.05) and the expression restricted to the cytoplasm was significantly higher in squamous cell carcinoma of the lower lip (p < 0.05).

Conclusion: The results of this study suggest that there is a marked decrease in the nuclear expression of ING3 as malignant progression occurs, indicating an impaired tumor suppressor function of this protein in actinic cheilitis and squamous cell carcinoma of the lower lip.

ING3 核免疫表达降低是唇癌发生过程中的常见现象
目的:评估ING3在下唇动眼神经炎和下唇鳞状细胞癌中的免疫组化表达:方法:对 45 例光化性咽颊炎标本和 48 例下唇鳞状细胞癌标本进行 ING3 免疫组化检测。比较两组不同细胞亚位的蛋白表达情况,并分析其与临床病理变量的关系。所有检验的显著性水平均为5%:结果:在组织病理学风险评分较高的肿瘤中,死亡人数明显较多(P 0.05)。下唇鳞状细胞癌的细胞核-细胞质 ING3 表达量明显低于口角炎(p 结论:下唇鳞状细胞癌的细胞核-细胞质 ING3 表达量明显低于口角炎(p):本研究结果表明,随着恶性程度的加深,ING3 的核表达明显降低,这表明该蛋白在动眼神经鳞状细胞癌和下唇鳞状细胞癌中的抑瘤功能受损。
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来源期刊
CiteScore
5.70
自引率
9.50%
发文量
99
期刊介绍: Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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