Optimization of image reconstruction technique for respiratory-gated lung stereotactic body radiotherapy treatment planning using four-dimensional CT: a phantom study.
IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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引用次数: 0
Abstract
Patient respiration is characterized by respiratory parameters, such as cycle, amplitude, and baseline drift. In treatment planning using four-dimensional computed tomography (4DCT) images, the target dose may be affected by variations in image reconstruction techniques and respiratory parameters. This study aimed to optimize 4DCT image reconstruction techniques for the treatment planning of lung stereotactic body radiotherapy (SBRT) based on respiratory parameters using respiratory motion phantom. We quantified respiratory parameters using 30 respiratory motion datasets. The 4DCT images were acquired, and the phase- and amplitude-based reconstruction images (RI) were created. The target dose was calculated based on these reconstructed images. Statistical analysis was performed using Pearson's correlation coefficient (r) to determine the relationship between respiratory parameters and target dose in each reconstructed technique and respiratory region. In the inhalation region of phase-based RI, r of the target dose and baseline drift was -0.52. In particular, the target dose was significantly reduced for respiratory parameters with a baseline drift of 0.8 mm/s and above. No other respiratory parameters or respiratory regions were significantly correlated with target dose in phase-based RI. In amplitude-based RI, there were no significant differences in the correlation between all respiratory parameters and target dose in the exhalation or inhalation regions. These results showed that the target dose of the amplitude-based RI did not depend on changes in respiratory parameters or respiratory regions, compared to the phase-based RI. However, it is possible to guarantee the target dose by considering respiratory parameters during the inhalation region of the phase-based RI.
患者呼吸的特点是呼吸参数,如周期、振幅和基线漂移。在使用四维计算机断层扫描(4DCT)图像进行治疗规划时,目标剂量可能会受到图像重建技术和呼吸参数变化的影响。本研究旨在利用呼吸运动模型,基于呼吸参数优化肺立体定向体放射治疗(SBRT)治疗计划的四维计算机断层扫描图像重建技术。我们使用 30 个呼吸运动数据集量化了呼吸参数。我们采集了 4DCT 图像,并创建了基于相位和振幅的重建图像 (RI)。根据这些重建图像计算目标剂量。使用皮尔逊相关系数(r)进行统计分析,以确定每种重建技术和呼吸区域的呼吸参数与目标剂量之间的关系。在基于相位的 RI 的吸入区域,目标剂量和基线漂移的 r 为-0.52。尤其是基线漂移在 0.8 毫米/秒及以上的呼吸参数,其目标剂量明显降低。在基于相位的 RI 中,没有其他呼吸参数或呼吸区域与目标剂量显著相关。在基于振幅的 RI 中,呼气或吸气区域的所有呼吸参数与目标剂量之间的相关性没有明显差异。这些结果表明,与基于相位的 RI 相比,基于振幅的 RI 的目标剂量并不取决于呼吸参数或呼吸区域的变化。然而,在基于相位的 RI 中,通过考虑吸气区域的呼吸参数,可以保证目标剂量。
期刊介绍:
The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.