HHV8-Associated Multicentric Castleman Disease: A Case Report on a Rare Complication of HIV in a Low-Income Setting.

IF 3.1 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Research and Reports in Tropical Medicine Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.2147/RRTM.S483426
Marcus Ground, Thijmen Veenendaal, Daniel Rexie Chiluzi, Geoffrey Nkhonjera, Arie C Glas, Lisanne Glas-van Dijk
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引用次数: 0

Abstract

We present the case of an HIV-positive man diagnosed with multicentric Castleman disease (MCD) associated with human herpesvirus 8 (HHV8) infection, complicated by renal failure. This subtype of an otherwise rare disease is a complication of HIV and HHV8 infection. The diagnosis and management of HHV8-MCD in the developing world is challenging-in part due to its rarity, but largely due to the limited access to histology and other laboratory services. Our case presented with a confusing constellation of symptoms and was diagnosed with MCD on histology. Here we discuss the epidemiology, pathogenesis, diagnosis, and treatment of HHV8-MCD in the context of HIV infection in a resource-limited setting, in the hope that greater awareness will lead to more prompt recognition.

HHV8相关多中心卡斯特曼病:低收入地区艾滋病罕见并发症的病例报告。
我们报告了一例艾滋病病毒(HIV)阳性男性患者的病例,他被诊断患有与人类疱疹病毒 8(HHV8)感染相关的多中心卡斯特曼病(MCD),并并发了肾功能衰竭。这种原本罕见的疾病的亚型是 HIV 和 HHV8 感染的并发症。在发展中国家,HHV8-MCD 的诊断和治疗具有挑战性,部分原因是其罕见性,但主要原因是组织学和其他实验室服务的获取途径有限。我们的病例出现了一系列令人困惑的症状,经组织学检查确诊为 MCD。在此,我们讨论了在资源有限的环境中,HIV感染背景下HHV8-MCD的流行病学、发病机制、诊断和治疗,希望通过提高人们对该病的认识,能够更及时地识别该病。
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来源期刊
Research and Reports in Tropical Medicine
Research and Reports in Tropical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
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审稿时长
16 weeks
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