Long-term follow-up MR imaging in children with transverse myelitis

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2024-10-11 DOI:10.1016/j.msard.2024.105926

Ines El Naggar , Robert Cleaveland , Andreas Panzer , Sandy Molenaar , Laetitia Giorgi , Eva-Maria Wendel , Annikki Bertolini , Michael Karenfort , Charlotte Thiels , Zuzana Libá , Matthias Baumann , Steffen Leiz , Adela Della Marina , Jan G. Hengstler , Kumaran Deiva , Rinze Neuteboom , Markus Reindl , Kevin Rostásy , BIOMARKER study group

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引用次数: 0

Abstract

Background

We recently described magnetic resonance imaging (MRI) features of children with transverse myelitis (TM) at first event with important and unique differences depending on the underlying disease entity.

Objective

To study the resolution of lesions over time in children with TM due to MOG-antibody associated disorders (MOGAD), multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) or double seronegative TM.

Patients and methods

In this prospective study, 78 children from 29 different medical centres with TM as part of MOGAD (n = 34), MS (n = 20), NMOSD (n = 5) and in double seronegative children (n = 19) were included. A grading system consisting of 4 grades (grade 0 = complete resolution; grade 3 = no resolution at all) was used to compare the degree of lesion resolution over time in the different disease entities. Time to lesion resolution was evaluated by Kaplan-Meier statistics and log-rank test.

Results

Significant differences of the interval between first MRI until resolution of lesions were observed between the four disease entities. The most rapid and complete resolution was seen in MOGAD, followed by double seronegative, MS and NMOSD. Median periods until total resolution (grade 0) were 191 days (MOGAD), 750 days (double seronegative), 1117 days (MS), while none of the patients with NMOSD reached a complete resolution during the observation period. The better prognosis of MOGAD compared to MS was independent of sex, age, oligoclonal bands and cell count in the multivariate Cox analysis (P < 0.001).

Conclusion

Children with TM and antibodies to MOG show a faster resolution of radiological lesions compared to children with MS and NMOSD.

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横贯性脊髓炎患儿的长期磁共振成像随访。

背景：我们最近描述了横贯性脊髓炎（TM）患儿首次发病时的磁共振成像（MRI）特征，不同的疾病实体会产生重要而独特的差异：研究因MOG抗体相关疾病（MOGAD）、多发性硬化症（MS）、神经脊髓炎视网膜频谱疾病（NMOSD）或双重血清阴性TM导致的横贯性脊髓炎患儿病变随时间推移的消退情况：在这项前瞻性研究中，纳入了来自 29 个不同医疗中心的 78 名 TM 儿童，他们分别患有多发性硬化症（MOGAD）（34 人）、多发性硬化症（MS）（20 人）、神经性脊髓炎视网膜病变（NMOSD）（5 人）和双血清阴性 TM 儿童（19 人）。该研究采用了由 4 个等级组成的分级系统（0 级=完全消退；3 级=完全消退）来比较不同疾病实体的病变消退程度。病灶消退时间通过卡普兰-梅耶统计和对数秩检验进行评估：结果：四种疾病实体之间从首次磁共振成像到病灶消退的时间间隔存在显著差异。MOGAD的病变消退最迅速、最彻底，其次是双血清阴性、MS和NMOSD。直至完全缓解（0 级）的中位时间分别为 191 天（MOGAD）、750 天（双血清阴性）和 1117 天（MS），而 NMOSD 患者在观察期内无一完全缓解。在多变量考克斯分析中，与MS相比，MOGAD的预后更好，这与性别、年龄、寡克隆带和细胞计数无关（P < 0.001）：结论：与患有多发性硬化症和NMOSD的儿童相比，患有TM和MOG抗体的儿童放射学病变的消退速度更快。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.