Accelerating de novo SINE annotation in plant and animal genomes.

IF 4.7 2区 生物学 Q1 GENETICS & HEREDITY
Herui Liao, Yanni Sun, Shujun Ou
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引用次数: 0

Abstract

Genome annotation is an important but challenging task. Accurate identification of short interspersed nuclear elements (SINEs) is particularly difficult due to their lack of highly conserved sequences. AnnoSINE is state-of-the-art software for annotating SINEs in plant genomes, but it is computationally inefficient for large genomes. Moreover, its applicability to animals is limited due to the absence of animal pHMMs in its HMM library. Therefore, we propose AnnoSINE_v2, which extends accurate SINE annotation for animal genomes with greatly optimized computational efficiency. Our results show that AnnoSINE_v2's annotation of SINEs has over 20% higher F1-score compared to the existing tools on animal genomes and enables the processing of complicated genomes, like human and zebrafish, which were beyond the capabilities of AnnoSINE_v1. AnnoSINE_v2 is freely available on Conda and GitHub: https://github.com/liaoherui/AnnoSINE_v2 .

加速植物和动物基因组中从头开始的 SINE 注释。
基因组注释是一项重要但极具挑战性的任务。由于缺乏高度保守的序列,准确识别短穿插核元素(SINEs)尤其困难。AnnoSINE 是注释植物基因组中 SINEs 的最先进软件,但它对大型基因组的计算效率较低。此外,由于其 HMM 库中没有动物 pHMMs,它对动物的适用性也很有限。因此,我们提出了 AnnoSINE_v2,它将精确的 SINE 注释扩展到动物基因组,并大大优化了计算效率。我们的研究结果表明,与现有的动物基因组工具相比,AnnoSINE_v2 的 SINE 注释 F1 分数提高了 20% 以上,而且还能处理人类和斑马鱼等复杂基因组,而这些都是 AnnoSINE_v1 所无法胜任的。AnnoSINE_v2 可在 Conda 和 GitHub 上免费获取:https://github.com/liaoherui/AnnoSINE_v2 。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mobile DNA
Mobile DNA GENETICS & HEREDITY-
CiteScore
8.20
自引率
6.10%
发文量
26
审稿时长
11 weeks
期刊介绍: Mobile DNA is an online, peer-reviewed, open access journal that publishes articles providing novel insights into DNA rearrangements in all organisms, ranging from transposition and other types of recombination mechanisms to patterns and processes of mobile element and host genome evolution. In addition, the journal will consider articles on the utility of mobile genetic elements in biotechnological methods and protocols.
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