Genomics unveils country-to-country transmission between animal hospitals of a multidrug-resistant and sequence type 2 Acinetobacter baumannii clone.

IF 4 2区生物学 Q1 GENETICS & HEREDITY

Microbial Genomics Pub Date : 2024-10-01 DOI:10.1099/mgen.0.001292

Amédée André, Julie Plantade, Isabelle Durieux, Pauline Durieu, Anne-Sophie Godeux, Maxence Decellieres, Céline Pouzot-Nevoret, Samuel Venner, Xavier Charpentier, Maria-Halima Laaberki

{"title":"Genomics unveils country-to-country transmission between animal hospitals of a multidrug-resistant and sequence type 2 Acinetobacter baumannii clone.","authors":"Amédée André, Julie Plantade, Isabelle Durieux, Pauline Durieu, Anne-Sophie Godeux, Maxence Decellieres, Céline Pouzot-Nevoret, Samuel Venner, Xavier Charpentier, Maria-Halima Laaberki","doi":"10.1099/mgen.0.001292","DOIUrl":null,"url":null,"abstract":"Acinetobacter baumannii is a globally distributed opportunistic pathogen in human health settings, including in intensive care units (ICUs). We investigated the contamination of a French small animal ICU with A. baumannii. We discovered repeated animal contamination by A. baumannii, and phylogenetic analysis traced contamination back to a potential foreign animal origin. Genomic analysis combined with antibiotic susceptibility testing revealed heteroresistance to penicillin and aminoglycoside mediated by insertion sequence dynamics and also suggest a potential cross-resistance to human-restricted piperacillin-tazobactam combination. The A. baumannii isolates of the animal ICU belong to the International Clone 2 commonly found in human health settings. Our results suggest a high adaptation of this lineage to healthcare settings and provide questions on the requirements for genetic determinants enabling adaptation to host and abiotic conditions.","PeriodicalId":18487,"journal":{"name":"Microbial Genomics","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472879/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbial Genomics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1099/mgen.0.001292","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Acinetobacter baumannii is a globally distributed opportunistic pathogen in human health settings, including in intensive care units (ICUs). We investigated the contamination of a French small animal ICU with A. baumannii. We discovered repeated animal contamination by A. baumannii, and phylogenetic analysis traced contamination back to a potential foreign animal origin. Genomic analysis combined with antibiotic susceptibility testing revealed heteroresistance to penicillin and aminoglycoside mediated by insertion sequence dynamics and also suggest a potential cross-resistance to human-restricted piperacillin-tazobactam combination. The A. baumannii isolates of the animal ICU belong to the International Clone 2 commonly found in human health settings. Our results suggest a high adaptation of this lineage to healthcare settings and provide questions on the requirements for genetic determinants enabling adaptation to host and abiotic conditions.

查看原文本刊更多论文

基因组学揭示了耐多药和序列2型鲍曼不动杆菌克隆在动物医院之间的国与国之间的传播。

鲍曼不动杆菌（Acinetobacter baumannii）是一种遍布全球的机会性病原体，主要存在于人类健康环境中，包括重症监护病房（ICU）。我们对法国一家小动物重症监护病房的鲍曼不动杆菌污染情况进行了调查。我们发现鲍曼不动杆菌反复污染动物，并通过系统发育分析追溯到潜在的外来动物来源。基因组分析与抗生素药敏试验相结合，发现了由插入序列动力学介导的对青霉素和氨基糖苷类药物的异质性耐药性，同时还表明可能存在对人类限制使用的哌拉西林-他唑巴坦类复方制剂的交叉耐药性。动物重症监护室分离出的鲍曼不动杆菌属于人类健康环境中常见的国际克隆 2。我们的研究结果表明，该菌株对医疗环境的适应性很强，并提出了有关适应宿主和非生物条件的基因决定因素的要求问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Microbial Genomics Medicine-Epidemiology

CiteScore

6.60

自引率

2.60%

发文量

153

审稿时长

12 weeks

期刊介绍： Microbial Genomics (MGen) is a fully open access, mandatory open data and peer-reviewed journal publishing high-profile original research on archaea, bacteria, microbial eukaryotes and viruses.