A fascination with tailless mice: a scientific historical review of studies of the T/t complex.

IF 2.7 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Mammalian Genome Pub Date : 2024-10-14 DOI:10.1007/s00335-024-10076-x

Robert P Erickson

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引用次数: 0

Abstract

The T/t complex of the mouse attracted many of the major figures of mouse genetics to perform genetic, cytogenetic, physiological, biochemical and molecular biological studies of it. These studies started with the discovery of short tailed mutants (Ts) and recessive lethal developmental mutations (ts) which mapped to the same "locus" in the early 1920s in France. However, due to the non-receptivity of French scientists to genetics, they continued to be studied in mostly Anglophone countries to be joined by a wider international community in the 1970s. These discoveries led to developmental studies of the lethal mutants which provided the origin of mammalian developmental genetics. The fascinating property of transmission ratio distortion (non-50/50 segregation of alleles in offspring of males) elicited tremendous interest. There were false leads (that the region consisted of unusual DNA, that the alleles controlled cell surface antigens on embryonic cells and spermatozoa) and exciting discoveries. This historical review provides a review of this extensive area of research and some of the individuals involved in it.

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无尾小鼠的魅力：T/t复合体研究的科学历史回顾。

小鼠的T/t复合体吸引了许多小鼠遗传学领域的重要人物对其进行遗传学、细胞遗传学、生理学、生物化学和分子生物学研究。这些研究始于 20 世纪 20 年代初在法国发现的短尾突变体（Ts）和隐性致死发育突变体（ts），它们映射到同一个 "基因座 "上。然而，由于法国科学家对遗传学不敏感，这些研究主要在英语国家继续进行，到 20 世纪 70 年代，更广泛的国际社会也加入了研究行列。这些发现导致了对致死突变体的发育研究，为哺乳动物的发育遗传学提供了起源。传递比失真（雄性后代中等位基因的非 50/50 分离）这一迷人特性引起了人们的极大兴趣。其中既有错误的线索（该区域由不寻常的 DNA 组成，等位基因控制着胚胎细胞和精子的细胞表面抗原），也有令人兴奋的发现。这篇历史回顾对这一广泛的研究领域以及参与其中的一些人进行了回顾。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mammalian Genome 生物-生化与分子生物学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.