The Effect of Sleep Duration and Excessive Daytime Sleepiness on All-Cause Dementia: A Longitudinal Analysis from the Hunter Community Study

IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY
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Abstract

Objectives

It has been proposed that abnormal sleep duration and excessive daytime sleepiness might be risk factors for dementia. This study assessed the interaction between sleep duration and excessive daytime sleepiness, and the effect of sleep duration in the presence or absence of excessive daytime sleepiness on dementia risk in community-dwelling older adults.

Design

A longitudinal study.

Setting and Participants

Data from 2187 community-dwelling participants with mean age 70 years from the Hunter Community Study were included in this study.

Methods

Participants were classified as participants with long sleep duration (slept >8 hours per night), recommended sleep duration (7–8 hours) as per the National Sleep Foundation, or short sleep duration (slept <7 hours per night). The Berlin Questionnaire was used to identify excessive daytime sleepiness. Dementia was defined as per International Classification of Diseases, 10th Revision codes. To calculate all-cause dementia risk, the Fine-Gray sub-distribution hazard model was computed with death as a competing risk.

Results

Over a mean follow-up of 6 years, 64 participants developed dementia and 154 deaths were identified. The average onset of dementia was 5.4 years. Long sleep duration was associated with increased dementia risk only in the presence of excessive daytime sleepiness (adjusted hazard ratio, 2.86; 95% confidence interval 1.03–7.91). A statistically significant interaction was found between excessive daytime sleepiness and sleep duration for all-cause dementia.

Conclusions and Implications

Long sleep duration with excessive daytime sleepiness was associated with increased risk of all-cause dementia. This suggests the importance of promoting awareness of healthy sleep and the possible role of nurturing good quantity and quality sleep in reducing the risk of dementia.
睡眠时间和白天过度嗜睡对全因痴呆症的影响:亨特社区研究的纵向分析
研究目的有人提出,睡眠时间异常和白天过度嗜睡可能是痴呆症的风险因素。本研究评估了睡眠时间与白天过度嗜睡之间的相互作用,以及在存在或不存在白天过度嗜睡的情况下睡眠时间对社区老年人痴呆症风险的影响:设计:纵向研究:本研究纳入了亨特社区研究中平均年龄为70岁的2187名社区居民的数据:根据入院和死亡数据,将参与者分为睡眠时间长的参与者(每晚睡眠时间大于8小时)、美国国家睡眠基金会推荐的睡眠时间(7-8小时)或睡眠时间短的参与者(每晚睡眠时间小于8小时)。为了计算全因痴呆症风险,计算了Fine-Gray子分布危险模型,并将死亡作为竞争风险:结果:在平均 6 年的随访期间,64 名参与者患上痴呆症,154 人死亡。痴呆症的平均发病时间为 5.4 年。只有在白天过度嗜睡的情况下,睡眠时间长才与痴呆症风险增加有关(调整后危险比为 2.86;95% 置信区间为 1.03-7.91)。就全因痴呆症而言,白天过度嗜睡与睡眠时间之间存在统计学意义上的交互作用:睡眠时间长且白天过度嗜睡与痴呆症风险增加有关。这表明,提高人们对健康睡眠的认识非常重要,培养良好的睡眠质量和数量对降低痴呆症的发病风险可能具有重要作用。
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来源期刊
CiteScore
11.10
自引率
6.60%
发文量
472
审稿时长
44 days
期刊介绍: JAMDA, the official journal of AMDA - The Society for Post-Acute and Long-Term Care Medicine, is a leading peer-reviewed publication that offers practical information and research geared towards healthcare professionals in the post-acute and long-term care fields. It is also a valuable resource for policy-makers, organizational leaders, educators, and advocates. The journal provides essential information for various healthcare professionals such as medical directors, attending physicians, nurses, consultant pharmacists, geriatric psychiatrists, nurse practitioners, physician assistants, physical and occupational therapists, social workers, and others involved in providing, overseeing, and promoting quality
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