Immunological dynamics in MASH: from landscape analysis to therapeutic intervention.

IF 6.9 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI:10.1007/s00535-024-02157-0

Lawan Rabiu, Pengchao Zhang, Lukman O Afolabi, Muhammad A Saliu, Salisu M Dabai, Rabiatu B Suleiman, Khalid I Gidado, Mark A Ige, Abdulrahman Ibrahim, Guizhong Zhang, Xiaochun Wan

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引用次数: 0

Abstract

Metabolic dysfunction-associated steatohepatitis (MASH), previously known as nonalcoholic steatohepatitis (NASH), is a multifaceted liver disease characterized by inflammation and fibrosis that develops from simple steatosis. Immune and inflammatory pathways have a central role in the pathogenesis of MASH, yet, how to target immune pathways to treat MASH remains perplexed. This review emphasizes the intricate role that immune cells play in the etiology and pathophysiology of MASH and highlights their significance as targets for therapeutic approaches. It discusses both current strategies and novel therapies aimed at modulating the immune response in MASH. It also highlights challenges in liver-specific drug delivery, potential off-target effects, and difficulties in targeting diverse immune cell populations within the liver. This review is a comprehensive resource that integrates current knowledge with future perspectives in the evolving field of MASH, with the goal of driving forward progress in medical therapies designed to treat this complex liver disease.

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MASH 的免疫动态：从景观分析到治疗干预。

代谢功能障碍相关性脂肪性肝炎（MASH），以前称为非酒精性脂肪性肝炎（NASH），是一种以炎症和纤维化为特征的多发性肝病，由单纯性脂肪变性发展而来。免疫和炎症通路在 MASH 的发病机制中起着核心作用，然而，如何针对免疫通路治疗 MASH 仍是一个难题。本综述强调了免疫细胞在 MASH 的病因学和病理生理学中扮演的复杂角色，并强调了它们作为治疗方法靶点的重要性。综述讨论了旨在调节 MASH 免疫反应的现有策略和新型疗法。它还强调了肝脏特异性给药、潜在的脱靶效应以及针对肝脏内不同免疫细胞群的困难。这篇综述是一份综合资料，整合了不断发展的MASH领域的现有知识和未来展望，旨在推动治疗这种复杂肝病的医学疗法取得进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

12.20

自引率

1.60%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal of Gastroenterology, which is the official publication of the Japanese Society of Gastroenterology, publishes Original Articles (Alimentary Tract/Liver, Pancreas, and Biliary Tract), Review Articles, Letters to the Editors and other articles on all aspects of the field of gastroenterology. Significant contributions relating to basic research, theory, and practice are welcomed. These publications are designed to disseminate knowledge in this field to a worldwide audience, and accordingly, its editorial board has an international membership.