Impact of text message reminders on immunosuppressive medication adherence among kidney transplant recipients: A randomized controlled study

IF 2.1 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

Journal of evaluation in clinical practice Pub Date : 2024-10-16 DOI:10.1111/jep.14178

Kübra Erdal MSc, Ebru Karazeybek PhD, RN

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引用次数: 0

Abstract

Background

One of the most common problems encountered in transplant patients is nonadherence with immunosuppressive drugs, one of the most important reasons for graft rejection.

Objective

The study aimed to assess the impact of text message reminders on medication adherence among kidney transplant recipients.

Design

A randomized controlled trial.

Participants

The study was conducted from January to October 2021. This study included a total of 100 patients receiving a kidney transplant, 50 in the intervention group and 50 in the control group.

Measurements

Patients in the intervention group were sent text message reminders four times a day during the 6th–9th months after transplantation. Control patients received no such intervention. Tacrolimus concentrations in the bloodstream were monitored for all participants through measurements taken at Months 7, 8 and 9. Data collection tools included Sociodemographic Form and Immunosuppressive Medication Adherence Scale.

Results

Patients were homogeneously distributed among the groups. Sending daily text message reminders to transplant recipients caused an independent positive effect on medication adherence scale scores at the end of the study. Mean pretest medication adherence score of all patients was 45.18 ± 4.22 and posttest score was 47.4 ± 3.6. The intervention group exhibited a significantly higher mean posttest adherence score compared to controls, with values of 48.68 ± 2.58 and 45.62 ± 4.42, respectively (p < 0.001). Findings demonstrated a substantial improvement in the final medication adherence scores of transplant patients when they received daily Short Message Service reminders, acting as an independent factor (β = 0.356, p < 0.001).

Conclusion

Sending text message reminders to kidney transplant recipients is a statistically and clinically effective intervention to improve immunosuppressive medication adherence.

Abstract Image

查看原文本刊更多论文

短信提醒对肾移植受者坚持服用免疫抑制剂的影响：随机对照研究。

背景：移植患者遇到的最常见问题之一是不坚持使用免疫抑制剂，这也是导致移植排斥反应的最重要原因之一：该研究旨在评估短信提醒对肾移植受者坚持服药的影响：设计：随机对照试验：研究于 2021 年 1 月至 10 月进行。该研究共纳入 100 名肾移植患者，其中干预组和对照组各 50 人：干预组患者在移植后的第 6-9 个月期间每天发送四次短信提醒。对照组患者不接受此类干预。通过在第 7、8 和 9 个月进行测量，对所有参与者血液中他克莫司的浓度进行监测。数据收集工具包括社会人口学表格和免疫抑制药物依从性量表：各组患者分布均匀。在研究结束时，向移植受者发送每日提醒短信对用药依从性量表评分产生了独立的积极影响。所有患者测试前的用药依从性平均得分为（45.18 ± 4.22）分，测试后得分为（47.4 ± 3.6）分。与对照组相比，干预组患者测试后的服药依从性平均得分明显更高，分别为（48.68 ± 2.58）和（45.62 ± 4.42）（p 结论：干预组患者的服药依从性平均得分明显高于对照组，分别为（48.68 ± 2.58）和（45.62 ± 4.42）：向肾移植受者发送短信提醒是一种在统计学和临床上有效的干预措施，可提高免疫抑制剂用药依从性。

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来源期刊

Journal of evaluation in clinical practice 医学-卫生保健

CiteScore

4.80

自引率

4.20%

发文量

143

审稿时长

3-8 weeks

期刊介绍： The Journal of Evaluation in Clinical Practice aims to promote the evaluation and development of clinical practice across medicine, nursing and the allied health professions. All aspects of health services research and public health policy analysis and debate are of interest to the Journal whether studied from a population-based or individual patient-centred perspective. Of particular interest to the Journal are submissions on all aspects of clinical effectiveness and efficiency including evidence-based medicine, clinical practice guidelines, clinical decision making, clinical services organisation, implementation and delivery, health economic evaluation, health process and outcome measurement and new or improved methods (conceptual and statistical) for systematic inquiry into clinical practice. Papers may take a classical quantitative or qualitative approach to investigation (or may utilise both techniques) or may take the form of learned essays, structured/systematic reviews and critiques.