A Wireless Miniature Injectable Device with Memory-Assisted Backscatter for Multimodal Animal Physiological Monitoring.

Abstract

This paper introduces a wirelessly powered multimodal animal physiological monitoring application-specific integrated circuit (ASIC). Fabricated in the 180 nm process, the ASIC can be integrated into an injectable device to monitor subcutaneous body temperature, electrocardiography (ECG), and photoplethysmography (PPG). To minimize the device size, the ASIC employs a miniature receiver (Rx) coil for wireless power receiving and data communication through a single inductive link operating at 13.56 MHz. We propose a folded L-shape Rx coil with improved coupling to the transmitter (Tx) coil, even in the presence of misalignment, and enhanced quality factor. The ASIC functions alternatively between recording and sleeping modes, consuming 2.55 μW on average. For PPG measurements, a reflection-type PPG sensor illuminates an LED with tunable current pulses. A current-input analog frontend (AFE) amplifies the current of a photodiode (PD) with 30.8 pARMS current input-referred noise (IRN). The ECG AFE captures ECG signals with a configurable gain of 45-80 dB. The temperature AFE achieves 0.02 ̊C inaccuracy within a sensing range between 27-47 ̊C. The AFE outputs are sequentially digitized by a 10-bit successive approximation register (SAR) analog-to-digital converter (ADC) with an effective number of bits (ENOB) of 8.79. To improve the reliability of data transmission, we propose a memory-assisted backscatter scheme that stores ADC data in an off-chip memory and transmits it when the coupling condition is stable. This scheme achieves a package loss rate (PLR) lower than 0.2% while allowing 24-hour data storage. The device's functionality has been evaluated by in vivo experiments.